利用DMAP催化於PEG-400中進行Quinoxalines及Methyl 2-oxo-2-arylethyl malonates 的合成研究

DMAP-Catalyzed Synthesis of Quinoxalines and Methyl 2-oxo-2-arylethyl malonates in PEG-400

鍾琪琳(Chi-Lin Chung)

指導教授 ： 陳麟慶

高雄醫學大學/藥學院/藥學研究所/碩士(2011年)

摘要

Quinoxalines的基本骨架在人類健康上是重要的，可作為許多殺蟲劑、殺菌劑和驅蟲劑，以及受體拮抗劑。methyl 2-oxo-2-arylethyl malonates是γ-butenolides的前趨物。γ-butenolide的骨架廣泛存在於天然物及具生理活性的合成化合物中。
聚乙二醇(polyethylene glycol; PEG)眾所皆知是價格便宜、可回收、無毒、具熱穩定性和生物相容性的聚合物；聚乙二醇於各種的有機轉化中，最常被當作支持物或是相轉移的觸媒，與典型的分子性溶媒相較，聚乙二醇是更環保有效的反應媒介。
本研究計劃是利用DMAP進行催化反應於PEG-400中合成目的物quinoxaline衍生物和methyl 2-oxo-2-arylethyl malonates.

關鍵字

4-二甲氨基吡啶 ； 丁烯酸內酯 ； 聚乙二醇

並列摘要

Quinoxalines constitute the basis of many insecticides, fungicides and anthelmintics, as well as being important in human health and as receptor antagonists.
Methyl 2-oxo-2-arylethyl malonates is the precursors of γ-butenolides. The r-butenolide structural subunit is present in a growing
number of natural products and synthetic compounds with wideranging
biological properties.
Polyethylene glycols (PEG) are well-known to be inexpensive, recoverable, non-toxic, thermally stable, and biological compatible polymers. Polyethylene glycols are most commonly employed as a support or a phase-transfer catalyst in various organic transformations. Compared with classical molecular solvents, the polyethylene glycols are environmentally benign reaction media.
In this work, catalytic reaction of DMAP and PEG-400 will be
applied to prepare quinoxaline derivatives and methyl 2-oxo-2-arylethyl malonates.

並列關鍵字

4-(Dimethylamino)pyridine (DMAP) ； γ-Butenolide ； Methyl 2-oxo-2-arylethyl malonate ； Poly(ethylene glycol) ； Quinoxalines

參考文獻

參考文獻

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