川芎茶調散與辛夷清肺湯之水煎劑劑型和科學濃縮製劑劑型藥物動力學研究

Pharmacokinetics Studies of Bioactive Constituents between Commercial Extract and Traditional Decoction of Chuan–Xiong–Cha–Tiao–San andShin–Yi– Ching–Fey Tang

方文孚(Wen-Fu Fang)

指導教授 ： 詹道明

高雄醫學大學/藥學院/藥學研究所/碩士(2012年)

https://doi.org/10.6832/KMU.2012.00015

摘要

本實驗目的研究辛夷清肺湯Shin Yi Ching Fey Tang (SYCFT)及川芎茶調散Chuan Xiong Cha Tiao San (CXCTS)這兩種方劑的水煎劑型及科學濃縮製劑型，在於投入體內中是否有相同的生物相等性。
在本實驗中所選定分析的指標成份分別為，Glycyrrhizin（甘草酸）, Baicalin（黃芩苷）及Ferulic acid（阿魏酸）。並且使用HPLC對投予公兔體內之Glycyrrhizin，Baicalin及Ferulic acid做血漿中之定量分析。
本實驗結果顯示出，甘草酸於川芎茶調散科學濃縮製劑中有較高的血中濃度。於辛夷清肺湯中，其水煎劑型之甘草酸較快達最大藥品吸收濃度的時間(Tmax)。於川芎茶調散中，其水煎劑型之阿魏酸較快達最大藥品吸收濃度的時間。黃芩苷於水煎劑或是科學濃縮劑中並無達到統計上顯著的差異。
結論，根據實驗結果科學濃縮製劑與水煎劑於體內有不同生物相等性，希望將來中醫師在給予不同劑型應當小心斟酌給予劑量。

關鍵字

甘草酸 ； 黃芩苷阿魏酸 ； 藥物動力學

並列摘要

The purpose of this study was to investigations of bioequivalence between of traditional decoction preparation and commercial extract﹐including Chuan Xiong Cha Tiao San (CXCTS) and Shin Yi Ching Fey Tang (SYCFT)﹒We choose the index components are Glycyrrhizin﹐Ferulic acid and Baicalin﹒In this study﹐HPLC methods were used for the quantitation of Glycyrrhizin﹐Baicalin and Ferulic acid in the rabbits plasma﹒
In the experimental results showed that the concentrations of the Glycyrrhizin in the CXCTS commercial extract are higher than CXCTS decoction preparation﹒The results indicated that Tmax of the Glycyrrhizin in the SYCFT decoction preparation are shorter than SYCFT commercial extract﹒The results also indicated that Tmax of the Ferulic acid in the CXCTS decoction preparation are shorter than CXCTS commercial extract﹒The concentrations of the baicalin are not different between the commercial extract and the decoction preparation﹒
In conclusion﹐because commercial extract and decoction preparation are different bioequivalence﹐therefore Chinese medicine practitioners in prescribing should be cautiously﹒

並列關鍵字

Glycyrrhizin ； Baicalin ； ferulic acid ； pharmacokinetics

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