單環γ-丁內醯胺及α-戊內醯胺質譜法之研究

Studies on the Mass Spectral of Monocyclic N-Aryl α,β-unstaturated

林國藩(Kuo-Fan Lin)

指導教授 ： 王英基

高雄醫學大學/藥學院/藥學研究所碩士在職專班/碩士(2003年)

摘要

中文摘要
本論文探討??取代???-不飽和γ-丁內醯胺 (N-Aryl α,β-unsaturatedγ-lactams) (Fig. 1)及??取代?-戊內醯胺(monocyclic N-Aryl-?-valero- lactams) (Fig. 2)等一系類化合物在電衝-質譜(EI-MS)中斷裂情況。除偵測它們的離子峰外，並探討γ-丁內醯胺之特徵碎片（fragments）如[M-29] +, [M-55] +, 與 [M+-82] + 及?-戊內醯胺之特徵碎片（fragments）如[M-29]+, [M-56] , [M-69] +, 和 [M-98] + 等在質譜 (EI-MS)中形成之機轉。並利用高分辨質譜(HRMS)測定各特徵碎片的化學組成以及其精確質量作為基石，進一步探討解釋各碎片行成之路徑。本研究結果除供構造確認以外，合理推論各碎片行成機構，可做為此等化合物定性鑑別的重要依據

關鍵字

電子撞擊游離髮質譜

並列摘要

英文摘要
ABSTRACT
The mass spectra of a series of N-Arylα,β-unsaturated γ-lactams (Fig 1), and monocyclic N-Aryl-?-valerolactams (Fig 2) were studied, respectively. Besides their molecular ion peak, together with their characteristic fragments such as [M-29] +, [M-55] +, [M-82] + and [M-29]+, [M-56] , [M-69]+, and [M-98]+ were found in EI-MS spectra, respectively. Furthermore, based on the exacted mass and chemical compositions of each fragment determined by high-resolution mass spectrometry (HRMS), the forming mechanism for the interpretation of each fragment was rational proposed. This result is expected to be useful information for further identification of N-Aryl α,β-unsaturatedγ-lactams and monocyclic N-Aryl-?-valerolactams.

並列關鍵字

EI-MS

參考文獻

六、參考文獻

1. Lin, S. T.; Lin, W. C.; Chao, Y. H.; Huang, C. L. J. Chin. Chem. Soc. 2000. 47, 907-912.

2. Lin, S. T.; Lin, M. L.; Lin, W. C. Org. Mass Spectrom. 1990, 25, 667-670.

3. Lin, S. T.; Wu, T. S. Org. Mass Spectrom. 1992, 27, 116-120.

4. Lin, S. T.; Lin, M. L.; Lin, W. C. Org. Mass Spectrom. 1991, 26, 583-586.