利用高價碘(III)試劑於PEG-400中進行2-Aminothiazoles 與 Quinoxalines之合成研究

Hypervalent Iodine(III) Reagent Mediated Synthesis of 2-Aminothiazoles and Quinoxalines in Liquid PEG-400

林佩穎(Pei-Ying Lin)

指導教授 ： 陳麟慶

高雄醫學大學/藥學院/藥學研究所/碩士(2009年)

https://doi.org/10.6832/KMU.2009.00026

摘要

高價碘(III)化合物由於是一種低毒性、方便使用、容易處理的反應試劑而廣泛被使用。其中以[hydroxyl(tosyloxy)iodo]benzene (HTIB) 、phenyliodine(III) diacetate (PIDA) 、phenyliodine(III) bis(trifluoroacetate) (PIFA)等最常被使用在合成化學。
聚乙二醇(polyethylene glycol; PEG) 眾所皆知是價格便宜、可回收、無毒、具熱穩定性和生物相容性的聚合物；聚乙二醇於各種的有機轉化中，最常被當作支持物或是相轉移的觸媒，與典型的分子性溶媒相較，聚乙二醇是更環保有效的反應媒介。
本研究計劃利用高價碘(III)試劑在PEG-400中進行2-aminothiazoles及quinoxalines衍生物的合成研究。

關鍵字

高價碘(III)試劑 ； 聚乙二醇

並列摘要

Hypervalent iodine(III) compounds have been extensively used in organic syntheses due to their low toxicity, ready availability and easy handling. [Hydroxyl(tosyloxy)iodo]benzene (HTIB), phenyliodine(III) diacetate (PIDA) and phenyliodine(III) bis(trifluoroacetate) (PIFA) are the most frequently used and easily available reagents in the family of iodine compounds.
Polyethylene glycols (PEG) are well-known to be inexpensive, recoverable, non-toxic, thermally stable, and biological compatible polymers. Polyethylene glycols are most commonly employed as a support or a phase-transfer catalyst in various organic transformations. Compared with classical molecular solvents, the polyethylene glycols are environmentally benign reaction media.
In this work, hypervalent iodine(III) reagents and PEG-400 will be applied to prepare 2-aminothiazoles and quinoxaline derivatives.

並列關鍵字

Hypervalent Iodine(III) Reagent ； PEG-400

參考文獻

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