透過您的圖書館登入
IP:18.117.100.20
  • 學位論文

以硝酸鈰銨將對-乙烯基酚經氧化偶合製備苯二氫呋喃

Preparation of dihydrobenzofurans via the oxidative coupling of p-vinylphenols with cerium ammonium nitrate

指導教授 : 王英基

摘要


本論文敘述將對-乙烯基酚經由氧化偶合反應(oxidative coupling)製備苯二氫呋喃(dihydrobenzofurans)。利用4-羥基苯甲醛(4-hydroxybenzaldehyde)及其衍生物作為起始原料,分別經由Wittig reaction以及crossed aldol condensation 製備 p-vinylphenols,再利用硝酸鈰銨試劑(cerium(Ⅳ) ammomium nitrate)進行氧化偶合,合成一系列苯二氫呋喃結構之化合物。

並列摘要


In this thesis, an improved method for the preparation of dihydrobenzofurans was described. The starting materials, p-vinylphenols was prepared from the corresponding p-hydroxybenzaldehydes via crossed aldol condensation or Wittig reaction in good yields. The p-vinylphenols were then treated with respectively cerium(Ⅳ) ammomium nitrate to undergo oxidative coupling to give dihydrobenzofurans in few minutes, and in moderated yields.

參考文獻


參考文獻
1. Chang, J. Y.; Chang, C. Y.; Kuo, C. C.; Chen, L. T.; Wein, Y. S. Mol Pharmacol. 2004, 65, 77-84.
2. Snider, B. B.; Han, L.; Xie, C. J. Org. Chem. 1997, 62, 6978
3. Wang, E. C.; Wein, Y. S.; Kuo, Y. H. Tetrahedron Lett. 2006, 47, 9195-9197.

延伸閱讀