蓮葉成分與生物活性之研究

Chemical and Bioactive Constituents from the Leaves of Nelumbo nucifera Gaertn cv. Rosa-plena

楊偉伶(Woei-Ling Yang)

指導教授 ： 楊世群

高雄醫學大學/藥學院/藥學研究所/碩士(2010年)

摘要

蓮是蓮科，廣泛種植於亞洲東部的多年生水生植物可作為食品和飲料。為了進一步了解蓮的化學分類，即選用此種粉紅花的栽培種蓮葉作為分析化學成分的對象。且目前未有以此科學名稱發表的成分分析文獻報導。從蓮葉中也分得幾種化合物，其中包括7個 aporphine類化合物，(-)-nuciferine (1), (-)-nornuciferine (2), (-)-asmilobine (3), (-)-N-methylasmilobine (4), (-)-caaverine (5), (-)-anonaine (6)和 (-)-roemerine (7); 2個 oxoaporphine類化合物，lysicamine (8)和liriodenine (9)，1個dioxaporphine類，cepharadione B (10)及1個dehydroaporphine類化合物，7-hydroxydehydronuciferine (11); 2個固醇類化合物，β-sitostenone (12)和stigmasta-4 ,22-dien-3-one (13)，2個葉綠素，pheophytin-a (14)和aristophyll-C (15)。其中一些分離出的成分，也是首次從蓮屬中分得，包括(-)-caaverine (5), lysicamine (8), cepharadione B (10)和7- hydroxydehydronuciferine (11)。針對這些化合物我們進行了，包括抗癌和抗氧化生物活性的測試。

關鍵字

蓮 ； Aporphine類化合物 ； 抗癌 ； 抗氧化

並列摘要

Nelumbo nucifera Gaertn is a perennial aquatic crop grown and consumed throughout Asia. All parts of N. nucifera have been used for various medicinal purposes in oriental medicine. In particular, the leaves are known for diuretic and astringent properties, and are used to treat fever, sweating, and strangury and as a styptic. To further understand the chemotaxonomy of the Nelumbo species, N. nucifera Gaertn cv. Rosa-plena was chosen for phytochemical investigation. However, there are no publications reported concerning the chemical component of this scientific name yet. There are several compounds derived from the leaves of N. nucifera, which include seven aporphines, (-)-nuciferine (1), (-)-nornuciferine (2), (-)-asmilobine (3), (-)-N-methylasimilobine (4), (-)-caaverine (5), (-)-anonaine (6) and (-)-roemerine (7); two oxoaporphines, lysicamine (8) and liriodenine (9); and one dioxoaporphine, cepharadione B (10); and one dehydroaporphine, 7-hydroxydehydronuciferine (11); two steroids, β-sitostenone (12) and stigmasta-4,22-dien-3-one (13); two chlorophylls, pheophytin-a (14) and aristophyll-C (15). Some of the isolated components from Nelumbo also have not been published, including (-)-caaverine (5), lysicamine (8), cepharadione B (10) and 7-hydroxydehydronuciferine (11). The bioactivities of this compounds, including anticancer and antioxidants were thus examined.

並列關鍵字

Nelumbo nucifera Gaertn cv. Rosa-plena ； aporphines ； anticancer ； antioxidant

參考文獻

1. 維基百科-

http://zh.wikipedia.org/zh-tw/%E8%8E%B2%E7%A7%91

2. 熊杰，簡明大英百科全書，台灣中華書局，1991。

3. 貝時璋等編，中國大百科全書-生物學Ⅱ，錦繡出版事業股份有限公司，2004。

4. 楊平世，光復彩色百科大典-植物與農藝2，光復書局，1982。