牙科樹脂複合表面鬚晶之磷酸鈣鹽顆粒於牙體贋復性質之研究

Dental resin reinforced with calcium phosphate particles of whiskers growth on surface in restoration dentistry

高士奇(Shih-Chi Gau)

指導教授 ： 陳文正

高雄醫學大學/口腔醫學院/牙醫學研究所/碩士(2010年)

https://doi.org/10.6832/KMU.2010.00102

摘要

本研究主要觀察四鈣磷酸鹽(tetracalcium phosphate, TTCP)、Bis-GMA與TEGDMA等雙甲基丙烯酸基(dimethacrylate)之壓克力樹脂在光起始劑(photoinitiator) - camphorquinone (λmax = 240-250nm)的存在下於波長254nm下照射進行光聚合反應，製備成複合材料，在不同的填料比例之下，所能承受的壓力，以及在冷熱循環（thermocycling）之後能承受壓力的變化。
　　實驗試片180片依照填料粒子對基質的重量百分比共分成七組不同的填料比例（30%，40%，50%，55%，60%，65%，70%）和三組控制組（0%，3M Z350 resin）；在進行冷熱循環之前，先將實驗試片浸於37℃蒸餾水中24小時，再於固定水溫5℃和50℃的水槽中，進行600次的冷熱循環;以萬能測試機測試未經過冷熱循環,以及冷熱循環後的樣本,記錄樣本初始破裂和折斷負荷，並利用電子顯微鏡觀察其斷面。
　　將實驗試片置於試管中，依重量添加5倍重的去離子水，於37℃恆溫中靜置24小時，以飽和海綿拭去多餘水分，並以電子天平測量重量，以酸鹼值測試儀測試其pH值。
　　分析實驗結果，發覺以冷熱循環模擬填補復形材料在口腔環境內半年的情形，其承受壓力的能力並未明顯減弱。在超過55%的填料粒子比例，能增加複合樹脂吸水性。pH值均呈現弱鹼性。以此體外實驗所測得之機械性質、吸水性和pH值的先期研究(pilot study)，期望能引領出後續更具有臨床參考價值的研究。

關鍵字

磷酸鈣鹽複合樹脂 ； 機械性質 ； 冷熱循環 ； 牙科 ； 復形

並列摘要

This study was aim to observe mechanical properties of the composite resin composed of calcium phosphate (CP) as a filler with Bis-GMA, TEGDMA, and photoinitiator as experimental group, no filler as a control group and commercialized products as comparative groups. The filler to matrix was in different filler/matrix ratio (30%, 40%, 50%, 55%, 60%, 65%, 70%) and cured by visible light (λmax = 240-250nm). Then evaluated fracture pattern, change of fracture load of samples before and after thermocycling.
Statistical analysis of variance showed that in most experimental samples after thermocyling, the fracture load did not decrease, but even slightly increased in experimental group. We conclude the CP reinforced composite dental resin could have a good bio-compatibility, and enough mechanical properties in vitro experiment, even after thermocycling that simulate a period of 6 month in oral cavity.

並列關鍵字

calcium phosphate composite ； mechanical properies ； thermocycling ； operative dentistry

參考文獻

1. Bowen RL. Properties of a silica-reinforced polymer for dental restorations.J Am Dent Assoc 1963;66:57–64.

2. Kinomoto Y, Torii M, Takeshige F, Ebisu S. Comparison of polymerization contraction stresses between self-and light-curing composites. J Dent 1999;27:383–9.

3. Hofmann N, Hugo B, Klaiber B. Effect of irradiation type (LED or QTH) on photo-activated composite shrinkage strain kinetics, temperature rise, and hardness. Eur J Oral Sci 2002;110:471–9.

4. Goldstein RE. Sistemas adhesives de los composites. En: Goldstein RE. Odontología estética vol I. Barcelona: stm Editores; 2002. p. 289-352.

5. Holter D, Frey H, Mulhaupt R. Branched bismethacrylates based on Bis-GMA. a systematic route to low shrinkage composites. Polymer Preprints 1997;38:84–5.