在水中直接利用鉑/羧酸催化苯胺類與烯丙醇類進行烯丙基化反應的研究

Direct Platinum/Carboxylic Acid-Catalyzed Allylation of Anilines with Allylic Alcohols in Water

詹凱鈞(Kai-Chun Chan)

指導教授 ： 楊世群

高雄醫學大學/藥學院/藥學研究所/碩士(2009年)

https://doi.org/10.6832/KMU.2009.00090

摘要

在水中進行有機反應最近非常受到矚目，不只是因為其獨特性，也因為水安全無毒，有取代有機溶媒的經濟價值。因此，環境安全的發展，以及在水中進行原子經濟反應是合成化學上重要目標之一。但無論如何，利用鉑金屬催化烯丙基化反應以水當溶媒卻鮮少被注意。
在本研究中，我們完成了在水中利用鉑金屬催化苯胺類與烯丙醇類化合物進行烯丙基化反應，而在反應中需加入催化量的酸添加試劑。

關鍵字

鉑金屬催化

並列摘要

Organic reaction in water have recently attracted much attention, not only because of its unique reactivity is often observed in water but also because water is a safe and more economic solvent for conventional Organic reaction. Thus, the development of environmental safe,atom-economical reactions in water is one of the most important goals of synthetic chemistry. However, platinum-catalyzed allylation has attracted little attraction.
In this study, we carried out the allylation of anilines with allylic alcohols in water in the presence of platinum as catalyst. A catalytic amount of carboxylic acid was needed as additive during the reaction.

並列關鍵字

platinum

參考文獻

1. MacKenzie, C. A.; Spialter, L.; Schoffman, RI. French Patent 961,816; Nov. 28, 1949.

2. Wagner, G. H. U. S. Patent 2,637,738; May 5 , 1953.

3. Speier, J. L.; Webster, J. A.;Barnes, C. H. J. Am. Chem. Soc. 1957, 79, 974.

4. Tsuji, Y.; Takeuchi, R.; Ogawa, H.; Watanabe, Y. Chem. Lett. 1986, 293.

5. Ghosh, A. K.; Matsuda, H. Org. Lett. 1999, 1, 2157.