- 學位論文
芋香林投化學成份及生物活性之研究
Studies on the Chemical Constituents and Bioactivites of Pandanus amaryllifolius
摘要
芋香林投為露兜樹科 (Pandanaceae) 露兜樹屬 (Pandanus) 植物，別名七葉蘭、班蘭葉或香林投，是一種原產於東南亞的熱帶植物，於1980年代自越南引進至台灣栽培。在越南、泰國、印尼及馬來西亞等地，常作為香料添加於食品中，除此之外，亦作為抗糖尿病、抗高血壓及抑制腫瘤等功效的民間用藥。 在先前的研究中發現，芋香林投之乙醇粗萃物在抗氧化，抗生物膜以及抗發炎等活性具有開發之潛力，並將此粗萃物以酸鹼萃取法分離出乙酸乙酯、二氯甲烷 (富含生物鹼)與水層。此次研究，針對高極性的生物鹼層分離出7個新化合物以及4個已知化合物。七個新化合物包括 pandamarines B 與 C (1與2)、pandalizines C–E (3–5)、及norpandamarilactonines E 與 F (6與7)。分離之化合物均藉由物化性質及光譜分析來進行結構解析。 這些生物鹼可分類成四種骨架，包括 pandamarines 1 與 2 、 indolizinones 3‒5、norpandamarilactonines 6‒9 及 pandamarilactams 10 與 11。在自然界中，產生的生物鹼通常都有特殊的生物活性。在本研究中，希望能找到芋香林投特殊的生物鹼所具有的活性。
並列摘要
Pandanus amaryllifolius Roxb. (Pandanaceae) is a tropical shrub that distributed in South-east Asia and introduced in Taiwan as a cultivated plant from Vietnam in 1980s. In Vietnam, Thailand, Indonesia and Malaysia, the plant is popular to be a kind of spices and folk medicine for hyperglycemia treatment, liver protection and tumor growth inhibition. In a previous study, the ethanolic extract of P. amaryllifolius aerial part showed potential antioxidant, anti-biofilm and anti-inflammatory activities. The extract was separated by an acid-base extraction method into EA, CH2Cl2 (alkaloid-rich) and H2O fractions. In this study, seven new compounds were further isolated from the alkaloid-rich fraction, including pandamarines B and C (1 and 2), pandalizines C–E (3–5), and norpandamarilactonines E and F (6 and 7), together with four known compounds. All of structures were elucidated by physical and chemical features as well as spectroscopic analysis. All of Pandanus alkaloids could summarize in four skeletons, including pandamarines 1 and 2, indolizinones 3‒5, norpandamarilactonines 6‒9, and pandamarilactams 10 and 11. In nature, alkaloids always play an important role to bioactivity. The functions of Pandanus alkaloids are under investigated.
參考文獻
延伸閱讀
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