正常人的尿酸與頸動脈硬化的關係

Relation between serum uric acid and carotid atherosclerosis in healthy persons

施曉雅(Hiu-Ngar Sy)

指導教授 ： 譚秀芬

長榮大學/健康科學學院/醫學研究所/碩士(2008年)

https://doi.org/10.6833/CJCU.2008.00156

摘要

目的: 探討在校正各種與頸動脈硬化相關的危險因子以後,正常人的血清尿酸值是否與頸動脈硬化有直接的關係 方法: 收集從2006年5月至2006年12月間, 從彰化基督教醫院健康檢查中心篩選出有接受高階健康檢查的健康人士; 其中一定包含頸動脈超音波與各種生物化學的檢查。 所收集的數據包括頸動脈超音波中的斑塊分數與內膜中層厚度,血清中的尿酸,血糖,三酸甘油脂,高密度膽固醇, 低密度膽固醇, 總膽固醇。統計上, 首先取得尿酸是否與各種心血管疾病的危險因之有相關。 再分析造成頸動脈硬化的相關因之, 最後執行羅吉斯回歸分析去評估尿酸是否造成頸動脈硬化的獨立因子。 結果: 去除有心血管疾病病史的個案, 半年內計有一仟人次(395位女性,605位男性)接受本院的高階檢查。有頸動脈硬化的女性與正常女性相比,血清中尿酸明顯偏高 (5.5 vs.4.8mg/dl, p<0.001); 但男性側沒有此一差異(6.5 vs.6.5mg/dl, p> 0.05)。 女性的血清尿酸跟年齡有明顯相關(r=0.320, p<0.001); 男性不會有此相關(r=-0.052, - 3 - p> 0.05)。 因尿酸平均值在兩性間存有差異, 故以各組尿酸值作四分位法去執行羅吉斯回歸分析。在把其他相關危險因子校正後, 各組尿酸四分位法與頸動脈硬化的勝算比比值沒有增加。 結論: 根據上述結果可以得知, 在台灣的健康男性或女性, 尿酸跟其他動脈硬化的危險因子一樣與頸動脈硬化有關聯。 但高血清尿酸卻不是一個動脈硬化的獨立危險因子。

關鍵字

血清尿酸 ； 內膜中層厚度斑塊指數頸動脈

並列摘要

OBJECTIVE:
The purpose of this study is to assess whether there was an independent association of SUA to carotid atheroclerosis in healthy individuals after adjusting for other confounding risk factors for atherosclerosis
Methods:
We retrospectively reviewed the medical records of who received health screen including carotid ultrasound. Participants with a history of CVD were excluded from the study. The biochemical data and report of carotid ultrasonography were collected from medical records. SUA level was compared among women/men with or without carotid atherosclerosis. Atherosclerosis prevalence as well as other risk factors was also compared among sex-specific quartile SUA groups using chi-square (for categorical variable) and ANOVA (for continuous variable). Finally, multivariate logistic regression model was used to investigate if quartile SUA is an independent risk factor for atherosclerosis after adjusting for
- 5 -
age, glucose, LDL, HDL and TG.
Result:
A total of 1,000 participants (395 female aged 18-78 years and 605 male aged 21-80 years) were recruited in this study. SUA was significantly higher in women with atherosclerosis than without (5.5 vs. 4.8 mg/dl, p<0.001) but not in men (6.5 vs. 6.5 mg/dl, p> 0.05). There was a significantly positive correlation between SUA and age in women (r=0.320, p<0.001), but not in men (r=-0.052, p> 0.05). Multivariate logistic regression showed no increased odds ratios across the sex-specific quartile SUA, after adjusting for other risk factors.
Conclusion:
These results suggested that, in both genders, there is an association between SUA and other risk factors for atherosclerosis, but hyperuricemia might not be an independent risk factor for atherosclerosis in healthy Taiwanese adults..

並列關鍵字

Serum uric acid ； Intima-medium thickness ； Plaque score ； Carotid artery

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