With steady economic growth, Vietnam has recently witnessed a significant increase in M&A activity and remained one of the most favorable destinations for foreign investment. Therefore, this research aims to explore the cross-border mergers and acquisitions transactions in Vietnam focused on motivations of both buy-side and sell-side. A conceptual framework is carried out to provide a synthesis of previous studies related to cross-border mergers and acquisitions. The research findings show that cross-border M&A in Vietnam are primarily motivated by facilitating faster entry into foreign market, market power and market access, synergies or other motives as growth and diversification, complementary resources…In addition, integral motivation of seller comes from the equitization and divestment plan of state-own enterprises (SOEs), which attracts foreign acquirers. A case study: M&A transaction between Saigon Beer-Alcohol-Beverage Joint Stock Corporation (Sabeco) and Thai Beverage is also analyzed in term of overview, deal structure, valuation and motivations behind.