A Signal Transmission and Monitoring System for Biomedical Brain-Machine-Interface Devices

王思忠(Shih-Chung Wang)

指導教授 ： 馬席彬

國立清華大學/電機資訊學院/積體電路設計產業研發碩士專班/碩士(2010年)

https://doi.org/10.6843/NTHU.2010.00056

摘要

For many brains injured or neural disorders patients, the electro-mechanical prostheses already successfully helped to restore their physiological functions. The most important reason is that electro-mechanical prostheses have stimulation and recording cellular functions. To stimulate interrelated neuron and observes neural reaction to restore the neural disorders, then improves of physiological function.

However, the stimulation and record circuits have been developed respectively for years, but the system lacks for integrated stimulation and recording circuits. Therefore, the aim of this thesis has integrated stimulation and recording circuits, and uses digital circuit and 5 wires to communicate with computer. The information of stimulating pulse are 4 shapes, voltage (0~4.75v), width (0~1.6ms), duration (0.1~10.23s), Bandwidth (1.5~36KHz) and fast settling of amplifier, and settings for each channel by the software interface directly. Besides, it can be observed neural signals for each channel in the computer.

Before integrated the system, I make a prototype and confirmed in biological experiments, then full system had taped-out in March 2010. To conclude, In terms of biological experiments in this study can be the simplest way to stimulate and record neural signals, user can understand more information of neuron.

關鍵字

神經刺激 ； 訊號傳輸 ； 監測系統

並列摘要

對於許多肢大腦受傷或者神經混亂的病人而言，神經電生理機電輔具已經可以成功幫助他們恢復部分生理功能。其中最主要的原因是 神經電生理機電輔具 具有刺激與紀錄多數細胞活動的功能，藉由刺激其他相關的神經來恢復原本混亂的神經，進而改善生理功能。

刺激電路與紀錄電路已經分別研發了好多年，但是將刺激與紀錄電路整合的系統卻是相當缺乏。因此本論文旨在將刺激電路與紀錄電路整合，並且利用digital core與5條線來跟電腦做溝通。而刺激的資料分別為波形(4種)，電壓(0~4.75v)，寬度(0~1.6ms),持續時間(0.1~10.23s)，放大器的bandwidth與fast setting與每個頻道的設定，都可以由使用者在軟體介面上直接設定，並且可以直接在電腦上觀察每個channel的神經訊號。

在整合系統之前，我有先製作一個prototype進行生物實驗，經由生物實驗證實可行性後，在2010年3月tape-out整個系統在同一個晶片上。總而言之，此研究希望能夠對於生物實驗而言，能夠以最簡單的方式來達到刺激與紀錄神經訊號的功能，使用者也可藉此進一步瞭解神經細胞的資訊。

並列關鍵字

stimulate neuron ； wired transmission ； Monitoring System

參考文獻

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