聚多巴胺奈米粒子合成與應用

Synthesis and applications of polydopamine nanoparticles

劉其麟(CHI-LIN LIU)

指導教授 ： 周芳如

中原大學/理學院/化學研究所/碩士(2020年)

https://doi.org/10.6840/cycu202100850

摘要

本研究利用聚多巴胺 (polydopamine, PDA)以製備成奈米粒子的型態，探討其表面吸附能力且做為奈米酶催化劑之應用。聚多巴胺奈米粒子本身除了具有全光譜之吸收、高黏附性之性質之外，本研究將利用不同種類的大分子及小分子在聚多巴胺奈米粒子的表面進行表面改質，開發其作為奈米酶之應用。如在本研究發現聚多巴胺奈米粒子可吸附亞甲基藍分子，由吸收光譜鑑定可發現分離後的藍色上清液在亞甲基藍分子特徵峰663 奈米時的吸收度相較於亞甲基藍分子溶液下降40%，當加入還原劑硼氫化鈉時，其吸收度可降至3.6%，展現聚多巴胺奈米粒子可作為奈米酶之催化亞甲基藍分子之能力。此外，本研究也利用聚多巴胺表面改質來探討其氧化催化反應，利用3,3',5,5'-四甲基聯苯胺 (TMB)的氧化反應，成功催化TMB變成氧化態TMB時，其顏色會從透明轉變成藍色，再加入硫酸中止反應成黃色之吸收光譜鑑定。實驗結果並顯示當聚多巴胺奈米粒子經過矽及普魯士藍進行表面改質可具有氧化催化能力。

關鍵字

聚多巴胺奈米粒子 ； 表面修飾 ； 催化 ； 亞甲基藍 ； 奈米酶

並列摘要

In this work, we aim to synthesize polydopamine nanoparticle via self-polymerization and to explore its potential of serving a nanozyme in the catalytic reaction. Polydopamine materials consist of whole-spectrum absorption and high adsorption; however, the catalytic property is yet to be explored. Thus, the surface modifications of polydopamine nanoparticles using different sizes of molecules are investigated. The polydopamine nanoparticle presents high absorption ability toward methylene blue, where the separated supernatant shows decreased absorbance (40%) of methylene blue at wavelength of 663 nm, in comparison to the solely methylene blue solution. Interestingly, the absorbance displays further decreased to 4% upon the addition of sodium borohydride, a reducing agent. The ten-fold absorbance difference may be attributed to the catalytic property featured by the polydopamine nanoparticles. In addition to the catalytic reduction reaction, the catalytic oxidation reaction is also confirmed by the silica- and Prussian blue-modified polydopamine nanoparticles.

並列關鍵字

polydopamine nanoparticles ； surface modification ； catalysis ； methylene blue ； nanozyme

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