大氣電漿應用於工業級和生醫級聚醚醚酮表面親水性改質之研究

The Study of Atmospheric Plasma to the Hydrophilic Modification of Industrial Grade and Biomedical Grade Polyetheretherketone

陳思安(Ssu-An Chen)

指導教授 ： 王明誠 ； 章浩宏

中原大學/工學院/生物醫學工程研究所/碩士(2019年)

https://doi.org/10.6840/cycu201900769

摘要

植牙是目前缺牙治療最常使用的方式，而目前市面上最接近人體骨骼的人工牙根為PEEK，但是其生物活性不佳，根據文獻可得知大氣電漿可以透過表面親水改質來達到生物活性的提升，故本研究利用大氣電漿對PEEK進行表面親水性處理，使之生物活性增加。本研究透過電漿物種檢測和溫度檢測進行大氣電漿設備的參數確定：物種檢測中發現了影響親水性的重要物種-活性氧物種(OH基、單態氧等)，且在氣壓0.1MPa功率1000W下活性氧物種的光譜是最強的；溫度檢測顯示電漿處理32秒內不會對玻璃轉換溫度150˚C的PEEK造成融化。在PEEK的化性結果發現工業級和生醫級PEEK並沒有差異；物性檢測中因製成的方式不同，導致其在毫米級的表面形態差異很大，確認完兩種等級的PEEK差異後，利用接觸角檢測選取未處理電漿的PEEK當接觸角大組，處理1.6秒電漿的PEEK當接觸角中組，處裡12.8秒電漿的PEEK當接觸角小組。選完電漿參數後進行材料改質後的表面分析，利用FE-SEM發現經電漿處理後的PEEK表面形態的奈米級顆粒變得更明顯，有文獻指出奈米顆粒可以提升細胞的貼付；因電漿的表面改質具有時效性，故進行退化實驗來看經電漿處理之PEEK的表面化學結構的退化趨勢，利用接觸角實驗可以發現：電漿處理後0小時為開始退化期，電漿處理後3小時為退化進行中，而電漿處理後9小時為退化趨於穩定期，利用這些參數來進行後續的表面分析。在ATR-FTIR分析可以發現此電漿不會對聚醚醚酮材料本身造成改變和損壞；利用XPS分析可以發現表面的碳含量會下降並且氧含量會上升，表示經大氣電漿處理後可以使更多的氧原子貼付在材料表面，並形成使表面變親水的O-C=O鍵結，且其C1s和O1s都不會因為時間的退化而造成表面化學結構的變化。

關鍵字

大氣電漿 ； 聚醚醚酮 ； 親水性 ； 表面改質 ； 表面分析

並列摘要

Dental implants are the most commonly used method for the treatment of lost teeth. The implant used in the treatment is PEEEK which is similar to the human bone property, but they have poor biological activity. According to the literature review, plasma can enhance the biological activity by surface hydrophilic modification. Therefore, the purpose of this study is to increase the surface hydrophilicity of PEEK by using atmospheric plasma. The parameters setting of plasma equipment were determined by plasma species test and plasma temperature test. The reactive oxygen species (ex. Hydroxyl and Singlet oxygen) found in the plasma species test are affecting the hydrophilicity and the strongest of ROS spectrum was occurred at air pressure of 0.1 MPa and power of 1000 W. The temperature test shows that the PEEK with a glass transition temperature of 150 ̊C will not melt within 32 seconds of plasma treatment. It is proved that no difference between industrial grade and biomedical grade PEEK under chemical property test. In the physical property test, the millimeter surface morphology between two grades are differentiable due to the different ways of preparation. After confirming the difference between the two grades of PEEK, the contact angle detection is carried out to select the plasma treatment time. The untreated PEEK as the contact angle large group, 1.6s plasma treatment as the contact angle middle group, and 12.8s plasma treatment as the contact angle small group. After the plasma parameters were selected, the surface analysis after material modification was carried out. Using FE-SEM, it was found that the nano-sized particles of the surface morphology of PEEK after plasma treatment became more obvious. Since the surface modification of the plasma is time-sensitive, the aging trend of the surface chemical structure of the PEEK treated by the plasma is observed. Using the contact angle experiment, it can be found that 0 hours after the plasma treatment is the aging start period, 3 hours after the plasma treatment is the aging period, and 9 hours after the plasma treatment is the aging stable period. These parameters are used for subsequent experiments. In the ATR-FTIR analysis, it can be found that the plasma does not cause changes and damage to the PEEK material. XPS analysis found that the carbon content on the surface decreased and the oxygen content increase which indicating that more oxygen atoms can be attached to the surface of the material after being treated by plasma. The formation of O-C=O bond makes the surface more hydrophilic, and the surface chemical structure has no change during aging.

並列關鍵字

atmospheric plasma ； polyetheretherketone (PEEK) ； hydrophilic ； surface modification ； surface analysis

參考文獻

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