- 學位論文
一個簡單基因瀏覽器設計 : 基因在染色體上之視覺化暨基因族群分析
The design of a simple genome browser : visualization of genes on chromosome and gene family analysis
摘要
由於越來越多的基因體序列被定序完成，因此基因體原始資料的分析工作變得極為重要。但在人類三十億的DNA序列中，約只有1.5~2%是基因，因此如何得到基因資訊及基因序列分析是一項重要的工作。在本論文中，我們以基因為單位，將染色體上已知及未知基因顯現在瀏覽器上，目前有Human、Mouse與Rat等物種可供瀏覽，且對於每個基因都可顯示其基本訊息(如基因的起始位置、終點位置、Exon個數及各個Exon的起始位置和終點位置等)，並可以選定的特定基因去找尋並顯示基因族群，希望將基因序列的資訊及其比較用圖型化的方式顯現出來，能提供分子生物學家找出一些基因規則。
關鍵字
基因瀏覽器設計並列摘要
As more and more genome sequences are sequenced and analyzed, annotations of genomic data become more important. It was estimated that only about 1.5~2% of the human’s 3 billion DNA sequences are genes, which are those DNA segments that could be translated into proteins. In this thesis, we will present the design and implementation of a genome browser that uses genes as units and displays the confirmed genes and unknown genes of selected chromosomes. Currently, the genomes of three species, human, mouse and rat can be selected and browsed. The basic attributes of each gene such as its beginning positions and end positions, numbers of exons, etc, can be shown. Similarly-based searches can be enabled to find family specific genes by comparing gene sequences using BLAST. The result can be displayed graphically and we hope this can help molecular biologists to find the regularity of genes.