This research selected a chemical industry in resin and additive manufacturing as the territory of case study on applying Lean Six Sigma D-Square MAIC (D2MAIC) model. After the application, product characteristic variation is reduced and capabilbity of precision of acrylic acid resin has been promoted 58.1%. Moreover, the customer complaint reply process cycle efficiency is improved from 34.9% to 62.1%. It has successfully proved that D2MAIC model is applicable to chemical industry and capable of creating remarkable performance. Besides, this research could be a reference of some case study when applying the solution of Lean Six Sigma to the other industries.