應用於食道癌診斷之吸收光譜檢測系統

Absorption-spectrum measurement system for the diagnosis of esophageal cancer

陳紹婷(Shao-Ting Chen)

指導教授 ： 許怡仁

中原大學/理學院/物理研究所/碩士(2010年)

https://doi.org/10.6840/cycu201000571

摘要

本研究之目的為利用吸收光譜進行食道檢體之檢測，並發展新型食道癌診斷技術。研究中設計一套二維光譜量測系統，系統所使用的光源為波長介於320-700 nm之氙燈，為一可見光波段之寬頻光源。利用系統中的二軸自動掃描平台，可對樣品進行二維掃描。該系統為一透射式光譜量測系統。本研究亦發展分析光譜相關性與評估組織癌化可能性之演算法。研究當中量測三組人體之正常與癌化食道檢體之吸收光譜，並透過分析各光譜間之相關性，定義正常與癌化食道組織之標準吸收光譜，且進一步利用標準光譜及演算法就各檢體之吸收光譜評估該組織癌化的可能性。

關鍵字

光譜分析 ； 光學診斷 ； 吸收光譜 ； 相關性 ； 食道癌

並列摘要

The objective of this research is to examine the esophageal tissues by means of absorption spectra, and to develop new techniques for the diagnostics of esophageal cancer. A two-dimensional absorption-spectrum measurement system was designed. A xenon lamp (230-700 nm) was used as a broadband light source in the visible region. By the use of a two-axis translation stage, the system can perform a two-dimensional scan. The spectrum measurement system is in a transmitted type. We also developed algorithms to analyze the correlation of spectra and to evaluate the possibility of malignancy of a tissue. The absorption spectra of three sets of both normal and cancerous esophageal tissues were measured. We defined the standard absorption spectra of normal and cancerous esophageal tissues with the analysis of the correlation between different spectra. Furthermore, we evaluated the possibility of malignancy of each tissue with the standard spectra and the developed algorithms.

並列關鍵字

correlation ； absorption spectrum ； optical diagnostics ； Esophageal cancer ； spectrum analysis

參考文獻

[4] Y. C. Ko, Y. L. Huatig, C. H. Lee, M. J. Chen, L. M. Litt, and C. C. Tsai, “Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan,” Journal of Oral Pathology and Medicine, Vol. 24, pp. 450-453 (1995).

[6] A. J. Cameron, C. T. Lomboy, M. Pera, and H. A. Carpenter, “Adenocarcinoma of the esophagogastric junction and Barrett's esophagus,” Gastroenterology, Vol. 109, pp. 1541-1546 (1995).

[7] J. M. Lee, Y. C. Lee, S. Y. Yang, W. L. Shi, C. J. Lee, S. P. Luh, C. J. Chen, C. Y. Hsieh, and M. T. Wu, “Genetic polymorphisms of p53 and GSTP1, but not NAT2, are associated with susceptibility to squamous-cell carcinoma of the esophagus,” International Journal of Cancer, Vol. 89, pp. 458-464 (2000).

[9] J. M. Lee, A. C. Lo, S. Y. Yang, H. S. Tsau, R. J. Chen, and Y. C. Lee, “Association of angiotensin-converting enzyme insertion/deletion polymorphism with serum level and development of pulmonary complications following esophagectomy,” Annals of Surgery, Vol. 241, pp. 659-665 (2005).

[11] J. M. Lee, T. Y. Liu, D. C. Wu, H. C. Tang, J. Leh, M. T. Wu, H. H. Hsu, P. M. Huang, J. S. Chen, C. J. Lee, and Y. C. Lee, “Safrole-DNA adducts in tissues from esophageal cancer patients: clues to areca-related esophageal carcinogenesis,” Mutation Research, Vol. 565, pp. 121 (2005).