多樣性2-羥基烷酸之不對稱合成的開發研究 : (R)-2-羥基十八烷酸之合成

Studies on the Development of the Asymmetric Synthesis of Various 2-Hydroxyalkonic Acids : Synthesis of (R)-2-Hydrooxyoctadecanoic Acid

鍾昀燊(Yun-Shen Chung)

指導教授 ： 蔡祐輔

中原大學/理學院/化學研究所/碩士(2017年)

https://doi.org/10.6840/cycu201700897

摘要

2-羥基烷酸結構(α-hydroxy acid)及其衍生物被廣泛應用於掌性化學和藥物等方面的研究開發；所以此類型結構的相關衍生物就具有相當高的經濟價值和重要性。
使用D-木糖當作起始物，利用掌性池塘的不對稱合成方法，快速建立主架構，經由Wittig 試劑建立末端具有雙鍵化合物；並使用GrubbsⅡ試劑引進所需長碳鏈，並根據以往實驗室的結果；將其缺點加以改進。本篇主要合成具有2-羥基的單元體，經13步得到目標物2-羥基烷酸結構。

關鍵字

2-羥基烷酸 ； 掌性池塘

並列摘要

2-hydroxy acid structure (α-hydroxy acid) and its derivatives are widely used in palm chemistry and drug research and development; so the structure of this type of derivative has a very high economic value and importance.
The use of D-xylose as a starting material, the use of asymmetric synthesis of palm pond method, the rapid establishment of the main structure, through the Wittig reagent to establish a terminal with double bond compounds; and the use of Grubbs Ⅱ reagents to introduce the required long carbon chain, The results of the laboratory; to improve its shortcomings. In this paper, a unit having a 2-hydroxyl group is mainly synthesized, and the target 2-hydroxyalkanoic acid structure

並列關鍵字

2-hydroxy acid

參考文獻

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