- 學位論文
以二氧化錫薄膜為基礎製作固態式二氧化碳感測器
Study on the fabrication of a solid state pCO2 sensor based on a SnO2 thin film
摘要
血液氣體檢測系統於各大醫院內之急診室及加護病房內皆有所使用，而二氧化碳於血液中含量高低係判斷急診病患之生理狀況生重要指標，目前雖有多樣之血液氣體檢測儀器，例如光學式及電化學式檢測儀，但其中仍以電化學式中之電壓式檢測為較佳及廣泛使用的方法，本論文係利用固態式二氧化錫/氧化銦錫酸鹼感測電極及二氧化錫碳酸鹼感測電極為基礎，並以高分子材料製作固態電解質薄膜及以矽膠為基礎製作之氣體選擇膜，研製二氧化錫/氧化銦錫二氧化碳感測器。此感測器係可於水溶液中量測二氧化碳分子之濃度，此外有鑑於電壓式二氧化碳感測器具有反應時間緩慢之缺點，故本論文於固態電解質薄膜中加入可催化水合反應之酵素碳酸酐酶，達到增快反應時間之目的，此固態式二氧化碳感測器之基礎原理係水中之二氧化碳分子穿透氣體選擇膜到達固態電解質薄膜，並與固態電解質薄膜內之水分子進行水合反應後釋放氫離子，造成固態電解值內之酸鹼值改變並由二氧化錫/氧化銦錫架構之酸鹼感測器進行偵測。 依據研究結果可得知此固態式二氧化碳感測元件介於pH 4至pH 8之間不受溶液酸鹼變化影響，以二氧化錫/氧化銦錫酸鹼感測電極為基礎製作之二氧化碳感測元件於線性量測範圍(0.5mM~50mM)之感測度約為42mV/decade，反應時間約為二至三分鐘，最小二氧化碳濃度量測極限約為0.26mM。以二氧化錫/碳酸鹼感測電極為基礎製作之二氧化碳感測元件於線性量測範圍(0.5mM~30mM)之感測度約為26mV/decade，反應時間約為二分鐘，最小二氧化碳濃度量測極限約為0.14mM。由研究結果可得知以二氧化錫/氧化銦錫之酸鹼感測電極及二氧化錫碳酸鹼感測電極為基礎製作之固態式二氧化碳感測器，其優點為製程簡單、操作穩定性良好、低製作成本及架構可進行微小化。
並列摘要
Blood gas is an important parameter for the human body, and the detection of blood gas is great interests in clinical analysis and applications. The device that developed for detect the carbon dioxide molecule in human blood was called blood gas pCO2 sensor. Although there are direct optical method and electrochemical method of blood gas pCO2 determination, the potentiometric methods are more selective and much more widely used. This study investigates the potentiometric solid state pCO2 sensor, which is used to measure the dissolved carbon dioxide in the solution. In this study, the pCO2 sensor was fabricated by tin oxide (SnO2)/ indium tin oxide (ITO)/glass pH electrode and tin oxide (SnO2)/ carbon pH electrode, the polymer material, and the silicone rubber material. The solid state pCO2 sensors are made by coating the solid electrolyte membrane on the surface of pH sensitive thin film, and a gas-permeable membrane was covered on the surface of the solid electrolyte membrane. Moreover, the solid electrolyte membrane is separated from the sample by the gas-permeable membrane, which is permeable to the carbon dioxide molecule. The carbon dioxide molecules diffuse through the membrane into the solid electrolyte membrane, and resulting pH change. The presented solid state pCO2 sensors have slow response time and stable voltage output. In order to overcome the disadvantages of the slow response time of the solid state pCO2 sensors, the enzyme carbonic anhydrase was doped in the solid electrolyte to accelerate the hydration. According to the experimental results, the sensitivity of the potentiometric SnO2/ITO-based pCO2 sensor was about 42mV/decade in the linear range of 0.5mM to 50mM dissolved CO2, and the response time (t95%) of the pCO2 sensors was about 2 minutes when the low bicarbonate concentration and enzyme were used to fabricate the SnO2/ITO-based pCO2 sensor. Moreover, the sensitivity of the potentiometric pCO2 sensor based on SnO2/carbon electrode was about 26mV/decade, and the response time (t95%) of the pCO2 sensors based on SnO2/carbon electrode was about 2 minutes. Furthermore, the advantages of the solid state pCO2 sensors are its easy fabrication process, capability operated in citrate solution, good stability, capable for mass production.
參考文獻
延伸閱讀
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