將含矽烷基雙亞硝基鐵錯合物固定化於聚碳酸酯基板

Immobilization of Silane - Containing Dinitrosyl Iron Complex on Polycarbonate Sheet

朱誼(Yi Chu)

指導教授 ： 魯才德

中原大學/理學院/化學研究所/碩士(2016年)

https://doi.org/10.6840/cycu201600421

摘要

一氧化氮在生物體內具有的重要功能性：包含血管舒張、神經傳導、血壓調控、殺死外來病原體等。在本研究中以雙亞硝基鐵錯合物(Dinitrosyl iron complex, DNIC)做為一氧化氮來源，並進一步將其固定化於生醫材料基板上以達到穩定釋放或控制釋放的效果。
將(3-Mercaptopropyl)trimethoxysilane做為配位體，快速合成出雙核形式的雙亞硝基鐵錯合物[Fe2(μ-(3-Mercaptopropyl)trimethoxysilane)2(NO)4] (RRE-MPTMS)，其IR吸收峰位於在1773 cm-1及1748 cm-1。在成功的合成出含MPTMS的雙亞硝基鐵錯合物後，進一步利用RRE-MPTMS上所含的甲氧基和聚碳酸酯基板偶合釋放出甲醇的反應，將其固定化於聚碳酸酯基板上。以XPS確定其表面元素組成，再用SEM觀察樣品表面，搭配EDS從表面出現的堆積物的元素組成確定了表面含有RRE-MPTMS。並且以Griess reagent測試了固定化雙亞硝基鐵錯合物的一氧化氮釋放能力，確定固定化在聚碳酸酯基板上的[Fe2(μ-(3-Mercaptopropyl)trimethoxysilane)2(NO)4]可以緩慢地持續釋放出一氧化氮。

關鍵字

雙亞硝基鐵錯合物 ； 固定化 ； 一氧化氮釋放

並列摘要

Nitric oxide (NO) plays a key role in biological functions including cardiovascular, respiratory and nervous systems. In this work, we successfully synthesized Silane – Containing Dinitrosyl iron complex (DNIC) as an NO donor which is further immobilized on polycarbonate sheet.
We use (3-Mercaptopropyl)trimethoxysilane as a ligand to synthesize [Fe2(μ-(3-Mercaptopropyl)trimethoxysilane)2(NO)4] (RRE-MPTMS). The shift of the IR νNO stretching frequencies from 1807 s, 1792 s, 1739 s, 1723 s cm-1 to 1773 s, 1748 s cm-1 (THF) in the reaction of substitution corroborated the formation of RRE-MPTMS. Then immobile RRE-MPTMS on Polycarbonate Sheet. The presence of RRE-MPTMS on Polycarbonate Sheet was comfirmed via UV-visible Spectrophotometer (UV-vis), Field Emission Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectrometer (EDS), High resolution X-ray Photoelectron Spectrometer /Auger Electron Spectrometer (XPS), and direct observation of the NO releasing reactivity. Notably, the release of NO from free RRE-MPTMS was extremely rapid than RRE-MPTMS@PC .

並列關鍵字

Dinitrosyl Iron Complex ； Immobilization ； NO release

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