The major active ingredients based on chemical synthesis or extracted plants are normally in traditional cosmetics. In the past decade, more and more products such as peptide become the major active ingredient in cosmetics. Considerable progress based on peptide has been made in biotechnology related industries. Peptide was used for in the market of anti-aging and anti-wrinkle that were generally recognized as the most nonirritant materials by dermatologist and plastic surgeon in 21th century. The peptide has significant effect when it used as an active ingredient in cosmetic product. For example, for anti-aging, it stimulates the proliferation of collagen and contraction pore….etc. There are more completed study and clinical trials on copper peptide. This report is aiming to make a update report on the application of peptide on cosmetics.