離子交聯之聚電解質於抗菌和黏著之應用

Ionically cross-linked polyelectrolytes in antimicrobial and adhesive applications

蔣家欣(Chia-Hsin Chiang)

指導教授 ： 張雍 ； 黃俊仁

中原大學/工學院/化學工程研究所/碩士(2016年)

https://doi.org/10.6840/cycu201600720

摘要

生醫材料是近年來在醫學上相當重視的課題，而其中具有殺菌性質的材料被廣泛的研究中，本實驗利用簡單易製備的方法合成含有殺菌功能與黏附性質的離子交聯膠，將帶有四級胺正電官能基的高分子(甲基丙烯醯氧乙基三甲基氯化銨，TMA)與雙離子高分子(磺基甜菜鹼，SBMA)做熱聚合反應，並結合帶六價負電鹽類(Hexametaphosphate，PP)溶液，由於正電與負電相吸產生相互作用力而形成離子交聯膠，本實驗以相圖表示其膠的相變化以及形成條件，並且對於離子交聯膠進行機械強度之測試，包括黏性、拉伸強度、水含量、瓦解條件等，並且探討離子膠對於表面上與溶液中的殺菌功能，同時將離子膠與細胞做反應，藉由毒性測試後得知離子膠是否為生物相容性質。
本實驗成功地製備多功能之離子交聯膠，在表面上可以有效殺菌在溶液中也同時有釋放殺菌劑之功能，更可以避免生物膜的形成，由細胞毒性測試得知此離子膠於低濃度下具有良好的生物相容性，於不同基材例如玻璃、塑膠、鐵等，具有良好的黏著性，且當膠受到摩擦力破壞時，待靜置後其結構會自我回復故黏性回升，另外在高濃度之氯化鈉水溶液的下易產生離子置換而使離子膠快速地瓦解，相對來說也是與環境響應的離子膠，因此，離子交聯膠可以作為生物醫學上同時含有殺菌功能、良好黏著力、生物相容性、適用於各基材、易瓦解之多功能聚電解質之離子交聯膠。

關鍵字

聚電解質:抗菌:黏著

並列摘要

The ability to kill bacteria is an important characteristic for biomaterials and medical devices. We report a multifunctional ionically cross-linked polyelectrolyte gel that possesses adhesive capabilities and antimicrobial. We synthesized poly((trimethylamino)ethyl methacrylate chloride(pTMAEMA))- co –sulfobetainemethacrylate(SBMA) (pTMA-co-pSBMA) copolymer to ionically cross-link with hexameta phosphate (PP). The gels form spontaneously when synthetic polycations, such as (pTMAEMA) are mixed with strongly bound multivalent anions like hexameta phosphate (PP). The special ion-pairing interactions in the gel give rise to a superglue like characteristic to almost all kinds of materials. For gel formation it is was found that when pTMA ratio is higher we can get the gel easier. Also when the water content is higher the gel becomes harder to disrupt by NaCl. On the other hand when pTMA ratio are smaller the gel were more environmental friendly showed by the disruption of the gel easily. The results from the viscosity of the gel showed that the gels’ viscosity can be restored to its initial state despite agitation by letting the gel rest for some time, this phenomena is also known as the thixotropic phenomenon. The antibacterial property of the gel was observerd when more pTMA was present in the gels. The ionic gel also exhibits cell viability at low concentration of the copolymer.
Therefore we have successfully synthesized the copolymer forms a gel easily by mixing anions. This ionic gel have multifunctional properties including its adhesive strength, antibacterial, and environmental friendly .

並列關鍵字

polyelectrolytes:antimicrobial:adhesive

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