聚四氟乙烯薄膜表面改質及其應用研究

Surface modifications of poly(tetrafluoroethylene) films and their applications

韓鈞傑(Chun-Chieh Han)

指導教授 ： 劉英麟

中原大學/工學院/化學工程研究所/碩士(2009年)

https://doi.org/10.6840/cycu200901141

摘要

Poly(tetrafluoroethylene)(PTFE)具有眾多優良之特性，但其表面之惰性及疏水性質，限制了應用的廣泛度，因此必須在其表面進行改質處理。
本實驗主要即為改質PTFE薄膜之疏水特性，並在PTFE薄膜表面接枝親水性及具溫度敏感性和具生物相容性等之功能性高分子。實驗第一部分，在PTFE薄膜表面接枝具有環氧基團(epoxy)之Poly
(glycidyl methacrylate)(GMA)，以製備出PTFE-g-PGMA薄膜；並利用環氧基團進行開環反應，將Poly(N-isopropylacrylamide)
(PNIPAAm)接枝於PTFE-g-PGMA薄膜表面，製備出PTFE-g-PGMA-
PNIPAAm薄膜；因為PNIPAAm高分子在水溶液中，具有LCST(Lower Critical Solution Temperatures)之特性(32℃)，因此接枝有PNIPAAm之薄膜PTFE-g-PGMA-PNIPAAm，也可以在不同溫度水溶液中，表現出溫度敏感的特性(35~40℃)，可以利用溫度之改變，控制PTFE薄膜表面孔洞之大小，藉以過濾不同大小之固體粒子。
實驗第二部分中，將具有生物相容性之高分子Poly
(sulfobetaine methacrylate)(PSBMA)，接枝於PTFE薄膜表面，製備PTFE-g-PSBMA-Br薄膜。因為SBMA分子本身具有良好之生物相容性，且SBMA分子本身也非常親水，因此接枝SBMA分子於薄膜表面，可以將PTFE薄膜表面改質為親水性表面；且因為接枝SBMA分子層極薄，因此可以維持PTFE薄膜本身的良好特性。結果顯示PTFE-g-PSBMA-Br薄膜在抗蛋白質吸附上，可以較原PTFE薄膜減少53%之蛋白質吸附量。
實驗中第三部分，利用氫氣電漿(hydrogen plasma)處理PTFE薄膜表面，利用表面氟基(F)做為原子轉移自由基聚合法(ATRP)反應之起始基，直接進行表面引發ATRP反應接枝具生物相容性及親水性高分子Poly(Polyethylene glycol methylether methacrylate)(PEGMA)於薄膜表面，製備PTFE-g-PEGMA薄膜，為首次證實可於PTFE薄膜表面直接進行表面引發ATRP聚合反應，擴展了PTFE改質的範疇。其後，也利用Reverse ATRP(R-ATRP)反應進行聚合反應接枝高分子PEGMA於PTFE薄膜表面，兩種方法都表現出活性聚合的特性。

關鍵字

聚四氟乙烯 ； 表面改質

並列摘要

Poly (tetrafluoroethylene) (PTFE) has many excellent features, but its surface is inert and hydrophobic nature, limits the application of a wide range of degrees, it is necessary to carry out on its surface modification processing. The present work is the modification of the hydrophobic properties of PTFE film and PTFE graft hydrophilic membrane surface and the temperature sensitivity and function, such as a biocompatible polymer. The first part of the experiment, in the PTFE film surface grafted with epoxy groups (epoxy) of Poly (glycidyl methacrylate) (GMA), to prepare a PTFE-g-PGMA films; and the use of epoxy groups to carry out open-loop response, the Poly (N-isopropylacrylamide) (PNIPAAm) was grafted PTFE-g-PGMA films prepared PTFE-g-PGMA - PNIPAAm film; because PNIPAAm polymer in aqueous solution with a LCST (Lower Critical Solution Temperatures) characteristics (32 ℃), therefore there is PNIPAAm grafted film of PTFE-g-PGMA-PNIPAAm, also in aqueous solution at different temperatures, the performance of the characteristics of a temperature-sensitive (35 ~ 40 ℃), the change in temperature can be used to control the PTFE film surface the size of holes in order to filter solid particles of different sizes. The second part of the experiment, the polymer will have the biocompatibility of Poly (sulfobetaine methacrylate) (PSBMA), grafted onto the PTFE film surface prepared PTFE-g-PSBMA-Br film. SBMA elements because of their good biocompatibility, and the SBMA is also very hydrophilic molecule, the SBMA graft molecules in the surface film can be modified PTFE film surface for the hydrophilic surface; and because the molecular layer very thin graft SBMA and therefore to maintain good PTFE film properties themselves. The results showed that PTFE-g-PSBMA-Br film in the anti-protein adsorption, it can be better than the original PTFE film of 53% reduction in protein adsorption. The third part of the experiment, the use of hydrogen plasma (hydrogen plasma) to deal with the surface of PTFE film using the surface of fluoride-based (F) as atom transfer radical polymerization (ATRP) of the initial reaction-based, direct response surface initiated ATRP access branch of a biocompatible and hydrophilic polymer Poly (Polyethylene glycol methylether methacrylate) (PEGMA) on the film surface to prepare PTFE-g-PEGMA film, for the first time proved to be the surface of the PTFE film surface initiated ATRP direct polymerization, the expansion of Modification of the scope of PTFE. Subsequently, also the use of Reverse ATRP (R-ATRP) graft polymerization reaction of PEGMA polymer film on the surface of PTFE, both methods have shown the characteristics of living polymerization.

並列關鍵字

ELISA ； RATRP ； ATRP ； PTFE ； modification ； thermo responsive

參考文獻

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