- 學位論文
矽單體組成對矽水膠薄膜性質與表面潤濕性質影響之研究
The Effect of Silicone Monomer on the Membrane Properties and the Surface Wettability of Silicone Hydrogel
摘要
矽水膠材料有高透氧性質及抵抗蛋白質沉澱的能力，為近年來隱形眼鏡發展的趨勢。但矽水膠材料疏水的特性容易滋生細菌，在臨床上會造成眼睛發炎等問題。故本研究以市售甲基丙烯酸-三(三甲基矽氧)矽丙酯做為矽水膠材料配方中的矽單體並添加甲基丙烯酸二羥乙酯，二甲基丙烯胺，二甲基丙烯酸乙二醇酯。為改善矽水膠材料表面的潤濕性並測試不同矽單體比例對材料性質之影響，本研究添加聚乙烯基吡咯烷酮於配方。當甲基丙烯酸-三(三甲基矽氧)矽丙酯含量由15 mol%增加至45 mol%時，材料的彈性模數也由0.22 MPa 提高為4.61 MPa，同時透氧率也由60 barrers提升至110 barrers，但含水率卻由48 %降低至13 %。這樣的結果可由配方三元相圖分析中可看出趨勢。在添加聚氯乙烯基吡咯烷酮的矽水膠薄膜，表面變得較潤濕，其接觸角由90 o降低至78 o。蛋白質吸附試驗中，使用蛋白質定量法分析，其結果顯示添加潤濕劑的矽水膠薄膜其蛋白質吸附含量比未添加的矽水膠薄膜低。另外在脂質吸附方面，其結果顯示當矽單體含量增加時，材料變得更疏水，脂質吸附的含量相對增加。在細胞毒性實驗結果，本實驗中的試驗組與市售隱形眼鏡比較後，在ASTM F-895標準判定皆屬於1級。由以上實驗結果可得知，材料表面的特性與配方中添加的單體成份及比例有關。當矽水膠材料添加潤濕劑後，改善了表面潤濕性。
並列摘要
Silicone hydrogel contact lenses are new generation contact lenses because of its high oxygen permeability and low protein adsorption, which could increase comfort during wear. These characteristic properties are all attributed to the surface properties of silicone hydrogel. The purpose of this study was to evaluate the effects of 3-(methacryloyloxypropyl)-tris(trimethylsiloxy)silane (TRIS) on the surface properties of silicone hydrogels. In addition, polyvinyl pyrrolidone (PVP) was employed as a surface wetting agent and its effect on the surface hydrophobicity of silicone hydrogel was observed. The silicone hydrogel membrane consisted of 2-hydroxyethyl methacrylate, N,N-dimethylacryl amide, ethylene glycol dimethacrylate and TRIS monomers. In the first part of this study, it was found that the modulus increased from 0.22 MPa to 4.61 MPa as the amount of TRIS increased from 15 to 45 mol%. In addition, the oxygen permeability (DK) of the silicone hydrogel membrane increased from 60 to 110 barrers and the water content decreased from 48% to 13% given the same conditions. Based on these results, a ternary phase diagram was plotted. On the other hand, the second part of this study showed that the wetting agent PVP can notably decrease the contact angle of the membrane from 90o to 78o, bringing its value close to that of conventional contact lenses. In the third part of this study, it was found that significantly low protein adsorption on the membrane was obtained. However, increased membrane adsorption of lipid was found as the TRIS content increased. Lastly, the in vitro cytotoxicity tests showed that the silicone hydrogel and the conventional contact lenses are of the same 1 class according to ASTM F-895 standard. In conclusion, the present study reports various surface properties as a function of the composition of silicone hydrogel. This study suggests that the selection of the TRIS composition depends on a compromise between Dk and the water content of the silicone membranes. Furthermore, a surface wetting agent may be used with silicon hydrogel so as to avoid dry-eye symptom.