輝光介電質放電之常壓電漿多層接枝雙離子仿生材料於聚四氟乙烯薄膜之研究

Modification of Expanded Poly(tetrafluoroethylene) Membranes with Layer by layer Biomimetic Zwitterionic Materials by Dielectric Barrier Discharge Atmospheric Plasma

鄭庭林(Ting-Lin Cheng)

指導教授 ： 魏大欽

中原大學/工學院/化學工程研究所/碩士(2018年)

https://doi.org/10.6840/cycu201800692

摘要

本研究利用真空電漿系統及線性常壓輝光介電質放電之電漿系統( Line Source DBD Plasma System )對基材聚四氟乙烯ePTFE( expanded polytetrafluoroethylene )進行表面活化並使用雙離子性高分子-硫代甜菜鹼（sulfobetaine methacrylate, SBMA）單體進行逐層電漿接枝( Layer by layer )程序，以製備仿生雙離子性薄膜。電漿處理之改質膜材利用接觸角量測儀、反射式傅立葉轉換紅外線光譜儀、掃描式電子顯微鏡、X射線光電子能譜儀、原子力顯微鏡、共軛焦雷射掃描式電子顯微鏡、界達電位量測儀等儀器分析改質膜材之物理性質、化學結構，在抗生物分子沾黏檢測的部分有蛋白質吸附、細菌、血液細胞貼附以分析改質膜材之抗生物分子沾黏能力，並探討改質薄膜之血液相容性以及做為傷口敷料之應用測試。
　　利用線性常壓輝光介電質放電之電漿系統成功製備了不同接枝單體層數薄膜，其改質條件分別為Layer 1、3、5、7。經由XPS與Zeta Potential的分析高分子單體經電漿接枝處理後的N/S與表面電位變化，得知所有改質條件之薄膜其表面電位均屬電中性，但可能因為接枝層數的上升以致於膜材受電漿能量蝕刻的程度不同，導致膜材Layer 7表面電位趨向偏正電荷。各改質條件膜材均在水合程度上獲得提升，且擁有降低生物分子沾黏之效。
在傷口癒合實驗中，針對四種接枝層數樣樣品進行研究，其中血液相容性最佳的Layer 7因其表面孔洞覆蓋導致透氣性不佳，也影響了傷口恢復速度。反觀改質膜材Layer 1、3具有與基材較相似的表面孔洞及透氣性質，因此成功的應用於傷口恢復且傷口前期恢復速度優於市售商用敷料。總結以上觀點，雖然共價接枝層數的上升可以使水合能力大有提升，但在接枝密度與表面孔洞結構上取得平衡是傷口癒合應用的一大指標。

關鍵字

常壓電漿 ； 雙離子 ； 抗沾黏薄膜

並列摘要

A line source atmospheric dielectric barrier discharge (LSADBD) plasma system was used to graft Sulfobetaine (SBMA) onto ePTFE expanded (poly(tetrafluoroethylene) membrane with method Layer-by-layer (LBL). The chemical structure, surface morphology of the modified ePTFE membranes were characterized by Reflectance Fourier Transform Infrared (Reflectance - FTIR), Scanning Electron Microscopy (SEM), Electron Spectroscopy for chemical analysis (ESCA), atomic force microscope (AFM) Laser Scanning Confocal Microscope (CLSM). The anti-biofouling properties of modified membranes were characterized by the protein adsorption of bovine serum albumin (BSA), fibrinogen and the attachment of the Bacteria and human blood cells.
After treatment with LSADBD, the LBL membranes possess zwitterionic property which were characterized by SEM, XPS and Zeta Potental. The modified membranes all have significant improvement in anti-fouling properties and nearly eletrical neautral . Because the grafted layer of Layer 7 was thicker, the etching effect from plasma was more obvious, and the Zeta potential of the membranes surface would tend to positive charge.
In the wound dressing experiment, Layer 7 had a lowest WVTR because the pores were covered by SBMA grafting layer. Layer 1、3 had a better wound recovery rate than Layer 7 and could be compared to commercial dressings. Although the increase of grafting density could increase the degree of hydration, the balance between grafting density and membrane pore structure was the most important for wound dressing applications.

並列關鍵字

DBD glow discharge ； zwitterionic ； anti-fouling membrane ； Layer by layer

參考文獻

參考文獻

Uncategorized References

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