即時監測細胞培養的生物電阻抗量測系統之研發

根據民國102年衛生署統計，十大死因排行榜中，惡性腫瘤位居第一名，而在2013年全世界抗癌藥物市場高達約674億美元，年增長率為9%，根據這項趨勢，可以看出由於罹癌的人數不斷增加，藥廠也會愈來愈重視癌症藥物開發，本研究的目的為利用生物電阻抗的理論與量測方法，設計出一套偵測細胞阻抗的系統，以即時的量測，來觀測細胞阻抗變化。在本系統中分為硬體與軟體部分;硬體部份的電路分為細胞電阻抗量測電路、類比多工器電路、類比轉數位電路、MCU及USB介面。另外，在系統硬體的電路與軟體部分都有進行嚴格的評估測試，讓系統的呈現出來的數據，將會是十分準確的。

關鍵字

癌症；細胞；電阻抗

並列摘要

According to the statistics reported by the Department of Health in 2013 that cancer held the first position of the top ten cause of death. On the other hand, in 2013, the global market for cancer drug is about US$ 67 billion and increases 9% annually. Based on these trends, people suffering from cancer have been increasing and drug development company has been paying more and more attention on drug development. Therefore, the aim of this study is to develop a device to real-time monitor the changes of cell during cell culture based on bioimpedance technique. The device is composed of hardware and software. The hardware includes a bioimpedance measurement circuit, analog-to-digital converter, multiplexer, microcontroller and a USB interface. Results should that the device is accurate.

並列關鍵字

Cancer ； Cell ； Impedance

參考文獻

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國際替代計量

即時監測細胞培養的生物電阻抗量測系統之研發

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