電化學製備二氧化錳網版印刷碳電極對磺胺二甲嘧啶的定量分析

Electrochemical preparation of MnO2 coated screen-printed carbon electrode for the determination of sulfamethazine

王俊宥(Chun-Yu Wang)

指導教授 ： 鄭淑華

國立暨南國際大學/科技學院/應用化學學系/碩士(2018年)

摘要

磺胺類藥物如磺胺二甲嘧啶(Sulfamethazine，SMZ)為廣泛應用於畜牧養殖中的制菌劑，研究指出此類制菌劑會對人體造成過敏、肺炎及使哮喘症狀增強等危害，因此國內衛福部對於各種磺胺類藥物皆有明確之殘留量規範。本研究以預氧化電極複合二氧化錳開發偵測SMZ的電化學偵測方式。
本研究使用網版印刷電極(screen-printed carbon electrode, SPCE)在高錳酸鉀的溶液中進行預氧化，利用循環伏安法(cyclic voltammetry, CV)做為預氧化之方式，利用CV在電位之間來回掃描進行氧化還原之特性，將溶液中錳酸根還原至電極表面形成MnO2，以此方式製備出預氧化複合金屬氧化物之修飾電極(SPCERD/MnO2)。以往的研究中，電化學進行預氧化以及修飾金屬氧化物為不同的步驟，而此篇論文將其合併為一步驟方式完成。
文獻指出MnO2具有氧化SMZ之能力，而本研究則利用預氧化電優秀的電化學活性以及MnO2本身對SMZ的氧化能力，藉由偵測SMZ的二聚體做為定量SMZ的訊號來源，搭配電化學偵測快速的優點，開發出一種造價便宜且製備過程簡單的電化學感測器。

關鍵字

電化學感測 ； 二氧化錳 ； 預氧化電極 ； 磺胺二甲嘧啶

並列摘要

Sulfonamides such as sulfamethazine (SMZ) are widely used as bacteriostatic agents in animal husbandry. According to the research, it has been pointed out that such bacteriostatic agents may cause allergies, pneumonia, and enhance the symptoms of asthma. The Ministry of Health in Taiwan has reported a clear residue specification for various sulfa drugs. In this study, a pre-oxidized electrode modified with manganese dioxide material was developed to detect SMZ electrochemically.
In this study, screen-printed carbon electrode (SPCE) was used for pre-anodization in potassium permanganate solution. Cyclic voltammetry (CV) was used as a pre-oxidation method. During the potential scanning processes, the manganate ions was reduced to form MnO2 and deposited onto the electrode surface. In this way metal oxide modified electrode (SPCERD/MnO2) was fabricated. In previous studies, electrochemical pre-anodization and metal oxide deposition were used as different steps. This paper combined them into a one-step approach.
MnO2 has been studied to be able to oxidize SMZ, and this study uses the excellent electrochemical activity of the pre-anodized electrode and the ability of MnO2 itself to oxidize SMZ, and the redox peak of SMZ dimers was used as quantitative signal. Along with the advantages of rapid electrochemical detection, we have developed a SMZ detection method that is inexpensive and simple.

並列關鍵字

electrochemical sensing ； manganese dioxide ； pre-oxidation ； sulfamethazine

參考文獻

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