水溶性錳紫質對醯胺咪嗪氧化反應的電催化作用

本論文利用電化學方法研究錳紫質 Manganese meso-tetrakis(dimethylimidazolium) porphyrin(MnTDMImP)的中間金屬離子在不同pH水溶液中的氧化還原，並利用透光薄層電化學(optically transparent thin-layer electrode,OTTLE)的技術來觀測光譜變化。結果顯示隨著pH值增加時，錳紫質中心金屬的氧化電位會往負電位偏移，中心金屬的價數隨著給電位的提高，分別產生MnIIITDMImP、MnIVTDMImP、MnVTDMImP的變化，並以電化學氧化的方法產生高氧化態的錳紫質。接著，以電化學氧化的方法，利用透光薄層電化學法觀測錳紫質Manganese meso- tetrakis(dimethylimidazolium porphyrin)(MnTDMImP)對醯胺咪嗪(carbamazepine,CBZ)進行加氧化的電催化效應，並對催化後的產物以LC-Mass 針對產物在管柱的滯留時間(retention time)與荷質比(m/z)與標準品進行比對與分析。結果顯示當錳紫質氧化為MnVTDMImP時，可催化醯胺咪嗪行環氧化反應形成CBZ-EP，而產生的CBZ-EP會再水解成CBZ-DiOH。

關鍵字

電化學；光譜電化學；醯胺咪嗪MnTDMImP

並列摘要

We reported the study on the electrochemical and spectral properties of Manganese meso-tetrakis(dimethylimidazolium) porphyrin(MnTDMImP). The results showed that the peak potential shifted negatively as the pH value increased. Manganese meso-dimethylimidazolium porphyrin were electrochemically oxidized to generate the respective oxo-metal complex, O=MnIV(TDMImP)(OH-) and MnV(TDMImP)(O2). We observe the cyclic voltammetry and spectroelectrochemistry characters of MnTDMImP containing carbamazepine(CBZ) in pH 9.80 buffer solution. The results have shown that the formal potential (E0) of MnV(TDMImP)(O2) / O=MnIV(TDMImP)(OH-) is + 0.86 V at pH 9.80. MnV(TDMImP)(O2) can catalytically oxidizes CBZ to give CBZ-EP by optically transparent thin-layer electrode(OTTLE) method.When CBZ-EP produced, CBZ-EP were partially hydrolyzed to CBZ-DiOH. The analyses of the reaction products were performed by LC-Mass.