Progress in pharmaceutical technology, access to treatment, and an aging population are the driving forces behind the growth of the Taiwan pharmaceutical market. Global budget payment system and drug price adjustment are the pressures on the operation of Taiwan's pharmaceutical companies. Pharmaceutical patents that will expire and breakthrough drugs are currently an important consideration for pharmaceutical companies to rethink product positioning and sales strategies. In the market, pharmaceutical companies enhance their competitiveness through mergers, acquisitions, and cooperation with other pharmaceutical companies. Within the company, pharmaceutical companies often respond to outside challenges by organizational changes. The purpose of this study is to explore the relevance between organizational changes and performance, employee turnover after they have undergone organizational changes. Through relevant literature review and case study analysis, the findings of this study are as follows: 1. Organizational change is not conducive to the stability of organizational members. 2. Organizational change is conductive to the sales of drugs.