This study examines the ETF trading strategies based on four indicators: (1) Stock trading volume, (2) ETF premium/ discount, (3) ETF scale and (4) VIX. Using Taiwan Top 50 ETF and CMONEY Trading Decision Support System for back test over the period from 12/2006 to 07/2016, this empirical study investigates 48 trading strategies and compares the performance of the strategies with market benchmark. It is found that seven trading strategies significantly perform better than the market index does. According to the back-test results, the total number of transactions is 71 times over the period from 12/2006 to 07/2016, and the number of profit is 59 times after trading costs are considered.