This thesis will focus on the relationship between space, place and the pioneers on the Great Plains in Laura Ingalls Wilder’s Little House books and Willa Cather’s My Ántonia. The frontier in the American West is where pioneers with different ethnicities and cultural backgrounds coexist and share multicultural experiences. The second-generation pioneer women in the two authors’ works are able to recreate new identities in the thriving little towns, which embodies the possibilities of plurality and fluidity of the Great Plains.