This study investigates the influence of job demands-resources toward burnout besides analyzing the moderating effect of workers’ genders and emotional intelligence on relationship between job demands-resources and burnout. By analyzing 118 valid questionnaires retrieved from the personnel of community-based psychiatric rehabilitation centers at Taipei City, this study reveals that: firstly, environmental demand and time demand of personnel have positive influence toward burnout while the job resources provided by the organizations (job autonomy, job growth and job support) have negative effect toward burnout; secondly, positive correlations of environmental demand and burnout for female are higher than male. In addition, negative correlations of job growth and burnout for male are higher than female. However, the negative correlations of job support and burnout for females are higher than male. This study also presents discussion on managerial implication emphasizing on the findings of the study.