A numerical investigation is performed into the mixed convection heat transfer characteristics of water based nanofluids confined within a lid-driven cavity. In the present study, the working fluid is assumed to be laminar flow, the boundary condition is assumed the upper and lower walls are both flat, insulated, and move horizontally, respectively. In addition, it is assumed that the left and right wavy-wall is maintained at high and low temperature, respectively. This study focuses on the respective effects of the dimensionless parameter, nanoparticle volume fraction, amplitude, aspect ratio and the waves number of the cavity. In addition, it investigates changes of the flow field inside the cavity through the streamline, heatline. Furthermore, it probes into the system irreversibility based on the second-law of thermodynamics, and uses entropy minimization method to assess the situation in this mixed convection cavity energy utilization.