- 學位論文
玻璃上生物相容性抗菌與抗汙混合自組裝薄膜製程研究與製程設備製作
Study of Mixed Self-Assembled Layers with Biocompatible Antibacterial and Antifouling Functions on the Glass and Manufacturing of Process Equipment
摘要
玻璃廣泛應用於產業與生活用品，例如生醫工程、微機電、感測器、光伏元件、公用觸控面板、眼鏡、各式窗戶等，若在玻璃鍍上一層具有抗污與抗菌的生物相容性功能薄膜，將可以增加美觀與愉悅感，並且避免疾病感染與環境汙染，促使玻璃性能應用面更廣，附加價值更高，更有綠色環保概念。過去某些單層自組裝薄膜其製程簡易，已被証明是具有抗污之可靠而穩定系統，然而混合自組裝製程在研究上僅有極少數成功的例子，因其製程因素相當複雜而不易控制。 本文以有機矽烷類材料混合抗菌藥劑附著玻璃表面上，建立混合自組裝分子薄膜技術及製造製程設備，俾利產業之應用。第一部份是製程極簡易、成本極低廉製造方式，利用田口方法在不同浸泡溫度、烘乾溫度、浸泡時間、自組裝藥劑濃度及抗菌藥劑濃度等影響因子下設計一最佳化製程，得到自組裝混合薄膜最佳接觸角度；OTS抗菌混合膜其接觸角為107.0°、ODS抗菌混合膜其接觸角為106.5°，表面黏附力均降為原來40%，並且薄膜之抗菌活性值分別為5.3與5.4，已高於產業與生活應用之標準。 第二部分比第一部份增加一道步驟，成本仍相對低廉，是使用溶膠凝膠法以TEOS作為前驅物，在控制pH值8~8.5、攪拌溫度70 ℃等適當條件下，製作SiO2薄膜進行玻璃的表面改質，其OTS表面接觸角度為152.5°已達超疏水程度，OTS抗菌混合膜接觸角度為147.5，改質後OTS添加抗菌混合膜其黏附力大幅下降至48.3 nN，並具備一定抗菌效果。 本文期望如同印表機與碳粉之營運模式，完成抗菌抗污鍍膜之原料、製程操作參數與機台的整合解決方案(Total solution)，因此第三部分是整合相關製程之機器，製作一台簡易適用於眼鏡行等小營業場所或家庭用之桌上型混合自組裝鍍膜機台；也製作一台可控制溫度、攪拌速度與時間之量產型製程機台，我們也使用此機台製作OTS與ODS混合薄膜，其接觸角與實驗室製程的誤差在1%以內，顯示製程參數的選定，極具穩定性，原料配方與機台製作亦具有基本量產能力。
並列摘要
Glass is widely applied in industries and life, such as biomedical engineering, micro electro mechanical system, sensors, photovoltaic components, public touch panels, glasses, windows and so on. If the glass is plated with a functional thin film with biocompatibility, it will improve beauty and sense of joy; avoid disease and environment pollution, so as to promote wider application of glass property, higher added value as well as more environment protection concept. In the past, the manufacture procedure of some single-layer self-assembled thin films is simple, which has been proved to have a reliable and stable anti-pollution system. Since the manufacture factors are quite complicated and difficult to control, the mixed self-assembled process has few successful examples. This paper establishes mixed self-assembled molecular membrane technology and manufacture processing equipments through attachment of organic silane materials mixed antimicrobial agent on glass, which is applied in industry. In the first part, it adopts a manufacture method with extremely simple manufacture process and extremely low cost, which utilizes the taguchi method to design an optimized manufacture process in influence factors such as soaking temperature, drying temperature, soaking time, self-assembled drug concentration and antimicrobial agent concentration, to get the optimal contact angle of self-assembled hybrid film; the contact angle of OTS hybrid film is 107.0° and the contact angle of ODS hybrid film is 106.5°, wherein their surface adhesive forces both decrease to 40% of the original and their antibacterial activity values of films are 5.3 and 5.4 respectively, which has been higher than the standards in the industry and life application. The second part has one more step. Its cost is still relatively low. It uses the sol-gel method and takes TEOS as a precursor to manufacture SiO2 for surface improvement of glass by controlling conditions that the pH value is at 8~8.5 and the mixing temperature is at 70℃. Its OTS surface contact angle is 152.5°, which has is super-hydrophobic. Contact angle of OTS antibacterial hybrid film is 147.5°. Through quality improvement, the adhesive force of OTS after adding antibacterial hybrid film decreases greatly to 48.3 nN and has certain antibacterial effect. This paper expects to complete a total solution of raw material, manufacture process operating parameters and the machine of the antibacterial and anti-pollution coating film as operation mode of the printer and carbon powder. Therefore, the third part integrates machines of relevant manufacture process to manufacture a simple desktop-type hybrid self-assembled coated machine applicable to small business places such as a glasses store or for domestic use; as well as a mass production machine capable of controlling temperature, stirring speed and time. We also use the machine to manufacture OTS and ODS hybrid film, whose contact angle has an error within 1% the same to that in laboratory, showing an extremely stable manufacture parameter, what’s more, raw material formulation and machine manufacture also have basic mass production ability.