- 學位論文
具生物相容性抗菌自組裝薄膜在光學鏡片之應用研究
Study of Biocompatible Molecular Films with Antibacterial in the Application of Optical Lenses
摘要
具有高穩定性且製作過程簡單的自組裝薄膜(SAMs)技術已被證實可控 制材料表面特性，通過自發性的吸附在基材上形成規則排列且緊密的有序單分子膜，近年來在多種領域中廣泛應用，如光學、電子學、生醫應用等，是現在國內外最熱門的研究焦點。 本論文研究是利用有機矽烷類的自組裝薄膜透過混合抗菌物質研究在 光學鏡片上自組裝薄膜的組織情形、透光率、表面清潔度及親疏水性的影響與挑選出最好的混合抗菌自組裝薄膜最佳使用條件。實驗中準備了五種自組裝膜分別為OTS、ODS、濃度50%抗菌藥劑、OTS加濃度50%抗菌藥劑、ODS加濃度50%抗菌藥劑，並分為表面經電漿界面強化處理與未處理兩組，進行臨界負荷、抗黏附力與接觸角實驗，研究結果發現：自組裝薄膜對光學鏡片之透光性質的影響極微小。在五種自組裝薄膜的接觸角實驗中，反應時間12小時，溫度為60℃時有最佳之效果，最大角度為ODS約117°，其餘依次為OTS、OTS+50%、ODS+50%與純抗菌50%分別為104°、96°、95°、61°。鏡片與自組裝薄膜的界面強化處理，可發現ODS自組裝薄膜、ODS混合濃度50%抗菌藥劑的臨界負荷可以提高51.1%、54.46%。由X射線光電子能譜儀實驗中可得知自組裝薄膜有於溶液中進行水解並鍵結形成薄膜在基材表面上，結果顯示自組裝薄膜成份於基材上確實有生長，並經由長時間置放達2.5個月再測量其接觸角，經由電漿處理使界面強化之鏡片其自組裝薄膜能存在於鏡片達2.5個月之久。因此總結以上結果，由ODS+Anti50%的混合抗菌自組裝薄膜其效果最好，從各實驗結果來看，ODS+Anti50%作為 表面處理的光學鏡片最能提高抗污、防水的功能及增強薄膜對於鏡面的附著性。
並列摘要
Production process with high stability and simple self-assembled technology has been confirmed to control the surface features. In recent years, it widely used in many fields such as optics, electronics, biomedical applications. The study of this work is using of biocompatibility antibacterial materials mixed with self-assembled monolayers grown on the optical lens. Study self-assembled film on the optical lens case organization, the transmittance, surface cleanliness and closeness water effects. The experiments in this study prepared five kinds of SAMs, ODS, OTS, Anti50%, ODS+Anti50%, OTS+Anti50%, and divided by the plasma-treated and untreated groups, to do the critical load experiments, adhesion experiments, contact angle experiments. These result indicated that the MgF2 coating can effectively reduce the refraction of light, increasing light ransmission rate from 93% to 97%. The result of experiment showed that in the contact angle of five self-assembled monolayers, the best contact angle of ODS was 117° after 12 hours at 60℃, and the contact angles of OTS, OTS+Anti50%, ODS+Anti50%, and 50% pure antibacterial solution, and control were 104°, 96°, 95°, and 61° respectively. By the enhanced treatment on the interfaces of lenses and SAMs, the result showed critical load of ODS and the ODS with 50% antibacterial solution could raise to 51.1% and 54.46%. By the X-ray photoelectron spectroscopy(XPS) experiments can be learned the self-assembled film has anti-bacterial agents solvent of ethanol and oxygen ions in the bond and the formation of film on the substrate surface, the results show that self-assembled film on the substrate composition film well. And by the long time of 2.5 months experiment and then to measure the contact angle, the enhanced plasma treatment to make the interface of the lens can be found the self-assembled films presence to 2.5 months on the lens. The data suggested, the surface treatment of optical lenses involving ODS with 50% antibacterial solution is the most capable of effectively increasing antifouling and antibacterial functions, and it also inhance the adhesion between films and lense surfaces.