This paper presents the use of Plethysmography measurement method, to achieve self-health check; we device the following two systems to measure human health problems. First of all we use the metal features of the resistive strain gauge to measure the blood pressure pulse waveform, to analyze the heart beat, which is the first portion of the system. The other portion uses the switching between two different wavelengths to achieve the synthesis of saturation of peripheral oxygen (SpO2), signal spectrum analysis(SER), and heart beat variability (HRV) analysis of non-invasive self-health monitoring device in real-time. This result was displayed on LCD screen, also including the SD signal storage function for a long time recording.