以雷射誘發爆破在微流道內研究其微流現象與流體行為

Studying microfluidic phenomena and fluid behavior in microchannels with laser-driven breakdown

江政樺(JHENG-HUA JIANG)

指導教授 ： 蘇冠暐

國立交通大學/理學院/電子物理系所/碩士(2019年)

摘要

生物醫學於21世界開始蓬勃發展，處處可見生物儀器或人工器官的研究，而生物儀器或人工器官的驅動一直以來都跟電相關，但在生物體內，電是一個極具危險性的驅動源，在過去，以雷射驅動來在微流道內微流現象、流體間的流速關係、氣泡現象等已在很多研究中討論過，在本論文中，我們利用 Q 開關鎖模的 Nd:YAG 雷射藉由相同的雷射波長所產生相同的能量閥值下誘發爆破在不同管徑寬度的高分子微流道，研究在不同管徑寬度的微流道下其微流現象及流體間的流速關係等，藉由我們研究的結 果，延伸討論血液在微流道中的微流現象及流速與微流道的寬度關係等，及由3D-Printing製造而成的微流道與以上關係等，進而討論未來以雷射遠端控制由3D-Printing製造客製化的生物儀器或人工器官的可行性與相關性等。

關鍵字

雷射 ； 微流道 ； 流體現象

並列摘要

Biomedicine has begun to flourish in the 21st world, and research on biological instruments or artificial organs can be seen everywhere, and the driving of biological instruments or artificial organs has always been related to electricity. In the past, laser-driven microfluidics in microchannels, the relationship between flow velocity between fluids, and bubble phenomena have been discussed in many studies. In this paper, we use Q-switched Nd: YAG mines Under the same energy threshold generated by the same laser wavelength, the polymer microchannels with different tube diameter widths are induced to blast. The microflow phenomenon and the flow velocity between fluids under the microchannels with different tube diameter widths are studied Based on the results of our research, we will extend the discussion of the microfluidic phenomenon of blood in microchannels and the relationship between the velocity and the width of microchannels, and the relationship between microchannels manufactured by 3D-Printing and the above. Discuss the feasibility and relevance of future laser remote control of customized biological instruments or artificial organs manufactured by 3D-Printing.

並列關鍵字

laser ； microfluidic

參考文獻

參考文獻:

[1]. Terry, S. C., Jerman, J. H., and Angell, J. B., IEEE Transactions on Electron Devices, 26(12), 1880-1886(1979).

[2]. Manz, A., Graber, N., and Widmer, H. M., Sensors and Actuators B, 1, 244-248(1990)

[3]. Manz, A., Fettinger, J. C., Verpoorte, E., Liidi, H., Widmer, H. M., and Harrison, D. J., Trends in Analytical Chemistry, 10(5), 144-149(199l).

[4]. Verpoorte, E. Manz, A., Liidi, H., Bruno, A. E., Maystre, F., Krattiger, B., Widmer, H.M., van der Schoot, B. H., and de Rooij, N. F., Sensors and Actuators B, 6, 66-70(1992)