This paper studies the robust reliable control issues base on integral sliding mode control approach. Integral sliding mode control is known to have better robustness than conventional sliding mode control, because integral sliding mode eliminates the reaching phase. Moreover, integral sliding mode control can combine with optimal strategy, such as linear quadratic regulator (LQR) approach, depending on engineer’s requirement to improve system performances. This nice property is extended in this paper to reliable control issues. Simulation results demonstrate the effectiveness of the proposed scheme by the attitude control of a spacecraft.