不同熱處理對鈦-六鋁-四釩合金之表面生物膜的影響

Effects of Various Heated Treatments on the Surface Biofilm of Ti-6Al-4V Alloy

歐汝鋒(Ou Ru-Feng)

指導教授 ： 趙志燁

國立屏東科技大學/工學院/機械工程系所/碩士(2021年)

https://doi.org/10.6346/NPUST202100464

摘要

近年來，許多學者研究鈦-六鋁-四釩合金之表面特徵，如：表面粗糙度、接觸角與表面能，對合金之生物膜或生物相容性的影響。根據學者的研究顯示：表面粗糙度約為20nm，接觸角大於50°以上，或表面能介於20.0 <γ<25.5 mJ/m2，相對的具有較佳的生物膜(Colony-Forming Unit，CFU；和Optical Density，OD)特徵。然而，鮮有學者探討合金的結構，生物膜或生物相容性的影響。本文主要的目的：利用不同熱處理，同時在固定的表面粗糙度下，分析鈦-六鋁-四釩合金的顯微結構與其表面生物膜的相關性。本文，研究結果顯示：合金經#5000砂紙研磨後，可獲致微觀表面粗糙度為61.48±3.12nm。合金經800~1040℃熱處理後，則可獲致不同比例之(α+β)、(α+α')、及α'相的組織結構；其間，α'相為高溫β相冷卻過程經麻田散體轉換形成。另，接觸角與表面能，分別介於46.62°~77.74°與7.99~20.09 mJ/m2之間。生物膜研究則顯示：OD與CFU值，分別介於0.09~0.17與0.85x107~5.65x107 CFU/mL之間。數據分析顯示：生物膜(OD與CFU值)特徵，與β相或α'相比例，呈現負相關性。另，鈦-六鋁-四釩合金具有完全α'相的顯微結構，具有最佳的生物相容性之特徵。
關鍵詞：鈦-六鋁-四釩、顯微結構、粗糙度、接觸角、生物膜

關鍵字

鈦-六鋁-四釩 ； 顯微結構 ； 粗糙度 ； 接觸角 ； 生物膜

並列摘要

Recently, the effects of surface characteristic such as sufface roughness, wetting angle and surface energy on the biocompatibility or biofilm of Ti-6Al-4V ELI alloy have been studies by many workers. Based on their studies, when the surface roughness is nearly 20μm, wetting angle is larger the 50°, or surface energy is between 20.0 < γ <25.5 mJ/m2, the Titanium or Titanium alloy would possess better property of biofilm. However, seldom information concerns with the effects of the microstructure on the biofilm of Ti-6Al-4V alloy. Therefore, the purposes of the present studies are focused on effects of various heated treatments on the surface biofilm of Ti-6Al-4V alloy. Based on the present studies, some results are described as following. The present alloy polished by #5000 sandpaper, the value of the micro-roughness would be a 61.48±3.12nm. When heated at temperature between 800 and 1040℃, the microstructures of the alloy could essentially be the (α+β), (α+α') and α'-phase with various ratio. Meanwhile, the α'-phase would transform form the β-phase during quenching prosesses. The values of wetting and surface energy would be in the range 46.62°~77.74° and 7.99~20.09 mJ/m2, respectively. Additionally, the values of OD and CFU would also be in the range 0.09~0.17 and 0.85x107~5.65x107 CFU/mL, respectively. Moreover, the relationship between the biofilm and microstructure of the present alloy would be inverse correlation. Meanwhile, the Ti-6Al-4V alloy belonging to the complete α'-phase structure would possess the optimum property of biocompatibility.
Keywords: Ti-6Al-4V, microstructure, roughness, wetting angle, biofilm

並列關鍵字

Ti-6Al-4V ； microstructure ； roughness ； wetting angle ； biofilm

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