Let LTQn denote the n-dimensional locally twisted cubes. This thesis deals with the problem of how to embed a family of two disjoint multi-dimensional meshes into locally twisted cubes. We develop the following embeddings: for n >= 3 and 2=k<=n, we show that two disjoint meshes each of size 2*2*...*2*2^n-k { k-1 } can be embedded into LTQn with unit dilation, unit expansion, and congestion-free. The results obtained are optimal in the sense that the dilations, expansions and congestions of all the embeddings are equal to 1.