含天然明膠之聚乙二醇甲基丙烯酸酯網路互穿型高分子之研究

The Interpenetrating Polymer Networks Based on Poly(ethylene glycol) methyl ether late and Gelatin

吳東翰(Dung-Han Wu)

指導教授 ： 江文彥

大同大學/工程學院/化學工程學系所/碩士(2005年)

摘要

天然明膠之聚乙二純甲基丙烯酸酯合成網路互穿型高分子，分別以N,N’-methylene bisacrylamide (NMBA) and glutaraldehyde 為交聯劑進行連續聚合反應。改變PEGMEA和Gelatin 含量作成比較的樣本。IPN 連續聚合反應中，以Ammonium Peroxydisulfate and N,N,N',N'- tetramethylethylenediamine做為起始劑，交聯劑NMBA對PEGMEA作第一次交聯，包含Gelatin的膠體浸泡在濃度為1% glutaraldehyde進行第二次交聯。實驗結果顯示膨潤度會隨著交聯劑的量增大而減小，機械性質和膨潤度也互相有著影響，對於膨潤度較小的膠體其機械性質也越強，在藥物釋放方面，膨潤度越小的膠體吸收藥物和放出藥物的能力也越差，而從SEM上可觀測到原本緻密的結構因為加入gelatin使得孔洞明顯化。

關鍵字

Gelatin ； IPN ； Hydrogel ； Interpenetrating Polymer Networks ； Poly(ethylene glycol) methyl ether acrylate.

並列摘要

This article describes the synthesis of interpenetrating polymer networks (IPNs) based on Poly(ethylene glycol) methyl ether acrylate (PEGMEA) and gelatin,which were crosslinked sequentially using N,N’-methylene bisacrylamide (NMBA) and glutaraldehyde, respectively. Various samples were prepared by taking varying amounts of PEGMEA and gelatin in the initial feed. Sequential IPNs were prepared by first polymerizing and crosslinking PEGMEA in the presence of gelatin using redox initiators (Ammonium Peroxydisulfate and N,N,N',N'- tetramethylethylenediamine) and NMBA as a crosslinking agent. Gelatin present in the firm gels was then crosslinked using 1% glutaraldehyde. Characterization of these gels was done by measuring their swelling behavior. Mechanical Behavior.Drug Release Behavior. and Scanning election micrographs.

並列關鍵字

明膠 ； 水膠 ； 網路互穿結構 ； 聚乙二醇甲基丙烯酸

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