Inject printing has high potential in the applications of flexible display and semiconductor manufacturing. The micro-droplet nozzle is key component of inject printing. The design of micro-droplet nozzle becomes the key for success of inject printing fitting application requirements. The fluid dynamic program FLOW-3D was integrated with differential evolution algorithm to construct a program for shape optimization of piezoelectric micro-droplet nozzle in this thesis. The shape and dimension of nozzle are used as design variables to encounter the different effects on the droplet. The objective of this study is to find out the optimum shape of nozzle including the effects of centralization、velocity、volume and satellite droplet. It is shown from the results of this study that the developed can find the optimum shape of nozzle for droplet requirement constraints