- 學位論文
含乙基維生素C微乳液之特性
Properties of Microemulsion Containing 3-O-Ethyl Ascorbic Acid
摘要
微乳液具有容易製備、穩定性高及提高生物可利用性等優點。本研究探討含有維生素C及乙基維生素C微乳液之特性，即於不同儲存溫度下，pH、黏度、粒徑、折射率、維生素C及乙基維生素C含量之變化；並比較乙基維生素C於微乳液及傳統乳液之經皮吸收差異性。結果顯示含乙基維生素C之微乳液在45℃儲存環境下 pH值明顯下降。含維生素C及乙基維生素C微乳液粘度、平均粒徑及折射率則不會因儲存溫度不同而有所變化；微乳液中維生素C含量於79天儲存後由1.98%降至約0%；乙基維生素C則無明顯減少。經皮吸收滲透性評估則以含乙基維生素C之微乳液滲透性較傳統乳液高。
並列摘要
Microemulsion is easy to prepare with high stability, and enhance the bioavailability. The properties of micoremulsion containing vitamin C and 3-o-ethyl ascorbic acid respectively, including pH, viscosity, mean particle diameter, refractive index during storage were determined in this study. In vitro transdermal penetration of 3-o-ethyl ascorbic acid in microemulsion was also compared with conventional emulsion. The results showed that pH of microemulsion with 3-o-ethyl ascorbic acid reduced at 45℃. However, changes in viscosity, mean particle diameter, refractive index of micoremulsion containing vitamin C and 3-o-ethyl ascorbic acid were not found during storage at 25 and 45℃. It was noted that the content of vitamin C in microemulsion decreased from 1.98% to ca. zero after storage for 79 d at 25 and 45℃. On the other hand, the content of 3-o-ethyl ascorbic acid was similar during storage. Transdermal penetration of 3-o-ethyl ascorbic acid in microemulsion was higher than that in conventional emulsion.