以電化學表面處理牙科用鈦金屬之研究

Examining electrochemical surface treatment on dental Titanium

曾文佑(Wen-You Zeng)

指導教授 ： 吳世經 ； 許學全

中臺科技大學/健康科學院/醫學工程暨材料研究所/碩士(2010年)

摘要

本研究針對純鈦與Ti-20Cr合金以電化學方法進行表面改質，目的是希望提昇金屬表面之生物活性。實驗共分二部份進行：第一部份是純鈦表面TiO2/HA鍍膜製作，首先利用硫酸溶液以定電壓將純鈦表面製作多孔狀結構，接著在表面製作氫氧基磷灰石(Hydroxyapatite, HA)鍍膜。結果顯示純鈦在3 M H2SO4電解液中，以定電壓100 V處理60分鐘，可得到均勻孔狀之結構。此結構以銳鈦礦與金紅石相之氧化鈦為主。表面具有多孔狀的純鈦於Ca(NO3)2．4H2O及(NH4)3PO4．3H2O混合液中，以-3 V電解沈積30分鐘可得到均勻鍍層，此鍍層結構以HA為主。耐蝕性方面，表面具有多孔狀或HA鍍層的純鈦在人工唾液中，與未處理純鈦比較具有較佳的耐蝕性。生物相容性方面，表面具有多孔狀或HA鍍層的純鈦，與未處理純鈦比較，具有較佳細胞貼附性以及細胞生長數。根據ASTM D3359–02分級下，表面經多孔氧化處理之試片，可有效提升HA鍍層之結合強度。第二部份是純鈦與Ti-20Cr合金表面微網狀結構製作，結果顯示純鈦和Ti-20Cr合金在3 M NaOH電解液中，以定電壓20 V處理5分鐘，可得到均勻微網狀之結構。在人工唾液的環境中，進行耐蝕性測試得到其具有微網狀結構的c.p. Ti與Ti-20Cr合金試片，與未處理純鈦比較皆具有較佳的耐蝕性。此製作微網狀結構之條件，可提供將來進一步在表層製作生物活性鍍層。

關鍵字

電化學方法 ； 鈦 ； 鉻合金 ； 氧基磷灰石

並列摘要

This study investigated surface modification on metal implants in order to enhance their bioactive properties. Clinical research was conducted according to the following two phases. First, hydroxyapatite (HA) was coated on an anodized surface of commercially pure titanium (c.p. Ti) by electrolytic deposition. Second, the micro-network structure of the Ti-20Cr alloy surface was anodized in a NaOH solution. As part of the first stage in this study’s research, the fabrication of a hydroxyapatite coating grown from an oxide structure was examined. An anodic oxide layer was grown on c.p. Ti with a surface anodized in 3 M of a H2SO4 solution at room temperature. This anodization process was carried out at 100 V potentials, resulting in a porous oxide structure. Hydroxyapatite was electrodeposited on the anodized surface of c.p. Ti, which formed an HA layer that adhered tightly to the surface. The corrosion resistance of c.p. Ti was also improved by the use of the anodization treatment, as analyzed by a potentio-dynamic polarization test. Finally, osteoblast-like cells that had cultured on the HA coating surface were found to have proliferated well. The second phase in this study includes the fabrication of a micro-network structure of the Ti-20Cr alloy’s surface by an electrochemical method. A Ti-20Cr specimen was anodized in NaOH. The surface of the anodized Ti-20Cr alloy displayed a micro-network structure. The aforementioned simulation exhibits a desirable combination of bioactivity, a low elastic modulus and low processing costs. Therefore this method of Ti-20Cr possesses promising applications for artificial bone substitutes or other hard tissue replacement materials that require heavy load-bearing properties.

並列關鍵字

hydroxyapatite ； electro ； Ti-20Cr alloy ； Titanium

參考文獻

[30] Lin F.H., Hon M.H., Liu H.C. Preparation and cell culture test of sintered β-TCP phosphate ceramic. Chem. Eng. Resear. Bullet. 1992; 5(7): 81-88.

[1] Zitter H. Corrosion behavior and biocompatibility of titanium alloys for implants. Materials and Corrosion. 1988; 39(12): 574-582.

[3] Parr G.R., Gardner L.K., Toth R.W. Titanium the mystery metal of implant dentistry. J. Prosthet. Dent. 1985; 54(3): 410-414.

[4] Solar R.J., Pollack S.R., Korostoff E. In vitro corrosion testing of titanium surgical implant alloys: an approach to understanding titanium release from implants. J. Biomed. Mater. Res. 1970; 13: 217-250.

[5] Rae T. The biological response to titanium and titanium-aluminum- vanadium alloy articles II. Long-term animal studies. Biomaterials 1986; 7(1): 37-40.