口腔癌在世界常見的惡性腫瘤中位居第11位,在診斷出為癌症的新病例中占百分之三,並且是具有高死亡率的癌症之一。本研究的目的是研究舌頭癌症組織(CTT)與其附近正常組織(NTT)的電特性。總共找了五位男性的舌癌病患參與了這項研究。所使用的拋棄式探針包含四個銀製電極,用來測量受測者CTT以及附近的NTT的電特性。在多頻率生物阻抗的量測中,使用的電壓最高為250mV,測量了20Hz、50kHz、1.3MHz、2.5MHz、3.7MHz和5MHz這六個頻率的數據。實驗所測量的參數為阻抗(Z)、相位角()、阻抗的實部(R)以及阻抗的虛部(X),用來評估CTT及附近的NTT是否存在統計學上顯著的差異。實驗結果發現CTT和附近的NTT在頻率50kHz的時候達到顯著水準(參數的P值小於0.05)。此外CTT的阻抗值(Z)和實部的電阻值(R)普遍比附近的NTT還低。總之生物阻抗技術在特定的頻率時具有舌癌篩檢的檢測技術之潛力和可行性。
Oral cancers are the 11th most common malignancy reported worldwide, accounting for 3% of all newly diagnosed cancer cases, and one with high mortality ratios among all malignancies. The objective of this study was to study the electrical properties of cancerous tongue tissue (CTT) and normal tongue tissue (NTT). Five tongue cancer patients participated in this study. A disposable probe incorporating four silver electrodes was used to measure electrical properties of CTT and surrounding NTT of patients. Measurements were performed at six frequencies of 20Hz, 50kHz, 1.3MHz, 2.5MHz, 3.7MHz and 5MHz, with the amplitude of the applied voltage limited to 250mV. Tongue impedance (Z), phase angle (), real part of impedance (R), and imaginary part of impedance (X) were assessed to see if significant difference in values obtained in CTT and surrounding NTT existed. A significant difference (p<0.05 for the four measurement parameters) was found at 50kHz between CTT and surrounding NTT. It was also found that Z and R of CTT were generally smaller than that of surrounding NTT. In conclusion, bioimpedance at a particular frequency is a potentially promising technique for tongue cancer screening.