The purpose of the study was to investigate the effect of prolonged endurance exercise on the biomarkers of marathon runner as well as the effect of age on the plasma biomarkers of marathon runner. Thirty athletes of the 2001 Taipei International Marathon volunteered to participate in the study, and 26 finished the race (42.195 km). Based on the age, 26 participates were divided into three groups: Young (20-39), Adult (40-49), and Senior (50-70). Blood samples were taken 12 hours before and immediately after the race, and then analyzed for lactate dehydrogenase (LDH), creatine kinase (CK), glucose, and lactate. After the race, all the biomarkers measured were significantly increased (P<.05). The concentrations of each biomarker measured after the race were: LDH (239.46±34.42 U/L), CK (307.65±141.07 U/L), glucose (113.46±28.76 mg/dL), and lactate (3.52±1.53 mmol/L), whereas those measured before the race were: LDH (177.96±30.35 UIL), CK (184.46±120.78 U/L), glucose (100.08±12.02 mg/dL), and lactate (1.25±0.50 mmol/L). After one-way ANOVA, the significant difference (P<.05) was found in the concentration of LDH between Young (263.5±33.0 U/L) and Adult (225.7±32.8 U/L) groups only. In conclusion, prolonged endurance exercise would significantly increase the concentrations of LDH, CK, glucose, and lactate. Tissue damage could be induced by a marathon race regardless of the difference in age.
The purpose of the study was to investigate the effect of prolonged endurance exercise on the biomarkers of marathon runner as well as the effect of age on the plasma biomarkers of marathon runner. Thirty athletes of the 2001 Taipei International Marathon volunteered to participate in the study, and 26 finished the race (42.195 km). Based on the age, 26 participates were divided into three groups: Young (20-39), Adult (40-49), and Senior (50-70). Blood samples were taken 12 hours before and immediately after the race, and then analyzed for lactate dehydrogenase (LDH), creatine kinase (CK), glucose, and lactate. After the race, all the biomarkers measured were significantly increased (P<.05). The concentrations of each biomarker measured after the race were: LDH (239.46±34.42 U/L), CK (307.65±141.07 U/L), glucose (113.46±28.76 mg/dL), and lactate (3.52±1.53 mmol/L), whereas those measured before the race were: LDH (177.96±30.35 UIL), CK (184.46±120.78 U/L), glucose (100.08±12.02 mg/dL), and lactate (1.25±0.50 mmol/L). After one-way ANOVA, the significant difference (P<.05) was found in the concentration of LDH between Young (263.5±33.0 U/L) and Adult (225.7±32.8 U/L) groups only. In conclusion, prolonged endurance exercise would significantly increase the concentrations of LDH, CK, glucose, and lactate. Tissue damage could be induced by a marathon race regardless of the difference in age.