黃耆對門脈高壓大鼠血液動力效應之研究

The Study of the Hemodynamic Effects of Huang-qi (Astragalus membranaceus)in Portal Hypertensive Rats

蘇奕彰(Yi-Chung Su) ； 林睿珊(Jui-Shan Lin) ； 紀美智(Mei-Jih Gee) ； 楊繼(Gy Yang)

《臺灣中醫醫學雜誌》 1卷2期 (2002/03) Pp. 85-117

摘要

本實驗的目的在評估黃耆對門脈壓力及全身血液動力效應之影響。造型採用部份門靜脈結紮法(Partial portal vein ligation, PVL)，誘導大白鼠產生門脈高壓狀態；將門脈高壓鼠隨機分為四組分別接受生理食鹽水、Propranolol(10mg/kg)、低劑量黃耆粗萃取物(0.1g/kg)，及高劑量黃耆粗萃取物(1g/kg)，觀察給藥前後門脈壓力、平均動脈壓，及心跳速率的變化。結果依序以多變量變異數分析、單變量區集化二因子變異數分析，及Duncan 事後比較分別比較門脈壓力、平均動脈壓，及心跳速率在不同治療組下，不同時間點作用差異。本研究之結果顯示：低劑量黃耆對門脈壓力、平均動脈壓無顯著影響，但有提升心跳速率之作用。高劑量黃耆對門脈壓力、平均動脈壓之作用為先上升後再下降至略低於給藥前之基準值，在心跳速率方面亦有提升之作用，與Propranolol降低門脈壓力、平均動脈壓，及心跳速率之作用不同。根據實驗結果，我們建議臨床上肝硬化病人服用大量黃耆時應更審慎評估。

關鍵字

門脈高壓 ； 黃旨 ； 血液動力效應

並列摘要

The purpost of this study was to investigate the hemodynamic effects of of Huang-qi in anesthetized portal hypertensive rats. Portal hypertension was induced by partial portal vein ligation in Sprague-Dawley rats. The portal hyper-tensive rats were randomly divided into four groups. Each group received normal saline, Propranolol(10mg/kg), low dose crew extract of Huang – qi(0.1g/kg), and high dose crew extract of Huang – qi (1g/kg),respectively. The changes of portal vein pressure(PVP), mean arterial pressure(MAP), and heart rate(HR)were observed. Statistical comparison was performed using the Multivariate Analysis of Variance, General Linear Model’s Procedure, and Duncan’s multiple comparison. Infusion of low dose of Huang- qi increased HR, but showed no influence on PVP and MAP. Infusion of high dose of Huang-qi first induced elevation of PVP and MAP, and then followed by reduction slightly from baseline. HR was also in-creased in group. The effects of Huang –qi are different from those of Pro-pranolol. Our results suggest that the patients with liver cirrhosis should be more careful when taking high dose of Huang-qi

並列關鍵字

Portal hypertension ； Huang -qi ； Hemodynamic effects