In this article, we will introduce a case of COVID-19 and share our experience on the diagnosis and therapy in traditional Chinese medicine (TCM). The 40 year-old female suffered from cough for 2 days. Successively, cough with sticky sputum, post-nasal drip, diarrhea, and poor appetite were noted. We prescribed mainly Ma Huang and Apricot Seed Combination (Ma Xing Gan Shi Tang), with the "Xuanfei Qingre" method and the outcome of her disease course was satisfied. We can approach the COVID-19 cases from both TCM and Western medicine perspectives, and it is quite interesting. Although COVID-19 has been known as a disease that primarily affects the lungs, it can also damage several other organs. Besides, Qi closure, phlegm coagulation and blood stasis seem to be major findings of pathogenesis in the theory of TCM.