Serum Eosinophil Cationic Protein in Patients with Bronchiolitis Caused by Respiratory Syncytial Virus

研究呼吸道融合病毒細支氣管炎之嗜酸性白血球陽離子蛋白

邱治平(Chih-Ping Chiu) ； 謝文斌(Wen-Bin Shieh) ； 林奏延(Tzou-Yien Lin) ； 黃璟隆(Jing-Long Huang) ； 顏大欽(Dah Chin Yan) ； 王志錄(Chih-Lu Wang) ； 李寧(Ning Lee) ； 陳國書(Kuo-Su Chen)

《中華民國兒童胸腔醫學會雜誌》 3卷4期 (2003/02) Pp. 58-63

https://doi.org/10.6322/JPRD.200302_3(4).0001

摘要

背景：呼吸道融合病毒（Respiratory Syncytial Virusl, RSV）是造成細支氣管炎最主要的病因，過去的研究顯示，RSV感染與嬰幼兒反覆性喘鳴及氣喘的發生有關，本研究主要是探討嗜酸性白血球蛋白質（Eosinophil cationic protein, ECP）和RSV細支氣管炎之關連及與疾病嚴重程度和氣喘之相關性。
方法：於本院小兒科住院之細支質管炎患者（年齡６個月至２歲）於住院後接受血液檢測CBC，D/C及血清中RSV及ECP濃度及胸部X-ray檢查，並以動脈血氧飽和度及症狀指數來評估疾病嚴重度。本研究收集了３７名RSV感染細支氣管炎做為實驗組，另選擇４０名RSV陰性細支氣管炎做為對照組以茲比較。
結果：顯示ECP濃度在RSV感染細支氣管炎（15.18±7.82）較RSV陰性組（9.91±6.13）為高且統計學上有顯著差異，（P=0.01）。血氧飽和度RSV感染細支氣管炎（90.19±3.99％）低於RSV陰性組（93.15±3.37％）另亦有統計學上之顯著差異，（P=0.01）。症狀指數在RSV感染細支氣管炎（2.54±1.14）亦較RSV陰性組（1.97±0.91）顯著為高，（P=0.019）。
討論：此研究顯示：嗜酸性白血球及相關之發炎反應可能在RSV感染細支氣管炎及疾病嚴重度扮演了重要角色。在臨床應用上使用抗發炎藥物，抑制嗜酸性白血球及其後讀發炎反應，以減少病毒性細支氣管炎之嚴重性及預防氣喘之發生，也許可提供做為未來細支氣管炎治療的新模式，值得進一步之臨床研究與觀察。

關鍵字

嗜酸性陽離子蛋白質 ； 呼吸道融合病毒

並列摘要

”Background: Bronchiolitis is a common cause of wheezing among infant. Respiratory syncytial virus (RSV) is the most common infectious agent to cause bronchiolitis. A significant proportion of these infected children will experience further wheezing episodes and increased in cadences of bronchial hyperactivity.
Methods: Thirty-seven children aged 6 months to 2 years admitted to our hospital due to RSV bronchiolitis were enrolled in this study. Blood samples were collected and analyzed. Forty children with RSV-negative bronchiolitis were selected as control for statistical analysis.
Results: The differences in serum eosinophil cationic protein (ECP) concentrations in bronchiolitis between children with RSV bronchiolitis (15.18±7.82 ug/L) and those with RSV-negative (9.9l±6.l3 ug/L) were significant statistically (p=0.01). There were significant lower in SpO2 between RSV-infected group (90. 19±3.99%) and RSV-negative group (93.15±3.37%) (p=0.0l). The symptom scores in children with RSV bronchiolitis (2.5±1.14) were significantly higher than RSV-negative (1.97±0.91) bronchiolitis (p=0.019).
Conclusion: The present study shows that eosinophils and their related inflammatory mechanism may play an important role in clinical severity and hypoxemia In RSV bronchiolitis. Administration of anti-inflammatory agents that inhibit migration and degranulation of eosinophils may be of clinical benefit.”

並列關鍵字

Eosinophil Cationic Protein ； Respiratory Syncytial Virus