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Usefulness of Bi-level Positive Airway Pressure by Nasal Mask in Infants with Acute Respiratory Failure

並列摘要


Objective: To evaluate the usefulness of Bilevel positive Airway Pressure (BiPAP) ventilator in the treatment of infants with acute respiratory failure.Materials and methods: All infants, admitted to the pediatric intensive care unit of Taichung-Veterans General Hospital with impending respiratory failure, that couldn't be corrected by full oxygen head box or nasal continuous positive airway pressure (NCPAP) support alone, were enrolled in this study from January 2005 to December 2006. They were all provided with BiPAP ventilator, spontaneous-timed mode and nasal bubble mask or nasal prong. Each patient served as her or his own control. Clinical and laboratory variables prior to and 6 hours after BiPAP application were compared. BiPAP ventilation failure was defined as inability to stabilize the progression of respiratory failure and then patient required endotracheal intubation.Results: A total of 11 patients were enrolled in this study. Mean age and bodyweight were 7.29±2.04 months old and 7.69±1.83 kg, respectively. The most common primary diagnosis was pneumonia. After BiPAP application the respiratory rate decreased significantly from 52.7±24.4 breaths per minute to 36.2±19.7 breaths per minutes (p<0.01). Among 11 patients, 5 patients finally required endotracheal intubation due to progressive respiratory failure. Conclusion: BiPAP is an effective and safe method of ventilation in infants and can reduce intubation rate up to 54.0%.

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